HitPredict

Interactor 1: RHOD (O00212)
Rho-related GTP-binding protein RhoD (Rho-related protein HP1) (RhoHP1)
Gene: RHOD

Interactor 2: DIAP2 (O60879)
Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2)
Gene: DIAPH2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	12577064, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Drf_FH3~Ras, Drf_GBD~Ras
Common GO terms	GO:0005769 - early endosome GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 210 Hs			1 1101
+	Hs
		1335331 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		DIAP3_HUMAN (13-1093): 0: 886: 56.56
+	Hs
		120664 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		DIAP3_HUMAN (13-1093): 0: 886: 56.56
+	Hs
		925658 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		DIAP3_HUMAN (13-1093): 0: 886: 56.56
+	Hs
		120589 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		FMNL2_HUMAN (91-1091): 0: 651: 22.60
+	Hs
		925531 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		FMNL2_HUMAN (91-1091): 0: 651: 22.60
+	Hs
		314892 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		FMNL1_HUMAN (30-1078): 0: 563: 19.45
+	Hs
		120260 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		FMNL1_HUMAN (30-1078): 0: 563: 19.45
+	Hs
		314858 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		FMNL1_HUMAN (30-1078): 0: 563: 19.45
+	Hs
		243113 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		DIAP2_HUMAN (619-1101): 9.22e-160: 504: 100.00
+	Hs
		243100 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		DIAP2_HUMAN (619-1101): 9.22e-160: 504: 100.00
+	Hs
		237625 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		DIAP1_HUMAN (1-626): 7.15e-126: 417: 42.10
+	Hs
		120231 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		DIAP1_HUMAN (1-626): 7.15e-126: 417: 42.10
+	Hs
		237586 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		DIAP1_HUMAN (1-626): 7.15e-126: 417: 42.10
+	Hs
		120730 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		DAAM1_HUMAN (616-1093): 2.01e-125: 412: 28.16
+	Hs
		1100147 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		INF2_HUMAN (604-1100): 3.15e-111: 377: 23.61
+	Hs
		120464 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		INF2_HUMAN (604-1100): 3.15e-111: 377: 23.61
+	Hs
		925315 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		INF2_HUMAN (604-1100): 3.15e-111: 377: 23.61
+	Hs
		1335350 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		FMN2_HUMAN (577-1053): 2.63e-98: 345: 23.65
+	Hs
		120677 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		FMN2_HUMAN (577-1053): 2.63e-98: 345: 23.65
+	Hs
		925673 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		FMN2_HUMAN (577-1053): 2.63e-98: 345: 23.65