HitPredict

Interactor 1: RHOD (O00212)
Rho-related GTP-binding protein RhoD (Rho-related protein HP1) (RhoHP1)
Gene: RHOD

Interactor 2: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~Ras
Common GO terms	GO:0000139 - Golgi membrane GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005741 - mitochondrial outer membrane GO:0005829 - cytosol and 1 others more... GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 210 Hs			1 189
+	Ce
		1089984 RHO1_CAEEL (19-192): 5.35e-89: 261: 54.02		RAP1_CAEEL (1-189): 6.18e-77: 229: 52.63
+	Hs
		120268 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		RASH_HUMAN (1-188): 6.53e-87: 255: 86.77
+	Hs
		120450 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		925294 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28
+	Hs
		895278 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97
+	Hs
		350049 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		RASK_HUMAN (1-189): 8.4e-77: 229: 100.00
+	Hs
		120373 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97
+	Hs
		895028 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97
+	Hs
		918952 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		RAB1A_HUMAN (4-187): 7.4e-74: 222: 34.36
+	Hs
		120378 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		RAB1A_HUMAN (4-187): 7.4e-74: 222: 34.36
+	Hs
		918847 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		RAB1A_HUMAN (4-187): 7.4e-74: 222: 34.36
+	Hs
		925600 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		RAB1B_HUMAN (4-187): 1.21e-73: 221: 32.47
+	Hs
		913995 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88
+	Hs
		564470 RHOQ_HUMAN (12-210): 7.44e-74: 223: 42.08		RAB1A_HUMAN (4-187): 7.4e-74: 222: 34.36
+	Hs
		897956 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		RAP1B_HUMAN (1-165): 1.02e-62: 193: 57.49
+	Hs
		120375 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		RAP1B_HUMAN (1-165): 1.02e-62: 193: 57.49
+	Hs
		897878 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		RAP1B_HUMAN (1-165): 1.02e-62: 193: 57.49
+	Hs
		506421 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		RALA_HUMAN (4-169): 5.37e-58: 182: 53.29
+	Hs
		564467 RHOQ_HUMAN (12-210): 7.44e-74: 223: 42.08		RAP1B_HUMAN (1-165): 1.02e-62: 193: 57.49
+	Hs
		925495 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		RIT1_HUMAN (3-176): 8.94e-56: 177: 50.29