HitPredict

Interactor 1: THOC6 (Q86W42)
THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58)
Gene: THOC6

Interactor 2: HECD1 (Q9ULT8)
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)
Gene: HECTD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29511261, 35915203
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 341 Hs			1 2610
+	Hs
		1346968 NLE1_HUMAN (2-329): 1.88e-73: 236: 11.81		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Hs
		197105 PRP4_HUMAN (2-244): 2.6e-52: 182: 12.65		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Hs
		236264 PRP17_HUMAN (1-284): 9.1e-50: 176: 8.67		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Hs
		1288384 SNR40_HUMAN (1-152): 5.89e-29: 116: 14.65		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Hs
		1281471 FBXW7_HUMAN (1-149): 4.03e-22: 99.3: 7.38		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Hs
		1246497 WDR36_HUMAN (18-259): 8.21e-18: 86.4: 17.00		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Hs
		903601 WDR5_HUMAN (1-103): 1.25e-14: 75.4: 13.76		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Hs
		304289 SNR40_HUMAN (1-152): 5.89e-29: 116: 14.65		UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94
+	Hs
		1246493 WDR36_HUMAN (18-259): 8.21e-18: 86.4: 17.00		HECW2_HUMAN (1360-2609): 2.26e-127: 444: 14.40
+	Hs
		304102 WDR5_HUMAN (1-103): 1.25e-14: 75.4: 13.76		UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94
+	Hs
		921057 GBB1_HUMAN (117-339): 5.07e-23: 99.7: 12.04		SMUF1_HUMAN (2220-2607): 1.5e-116: 391: 19.70
+	Hs
		1246481 WDR36_HUMAN (18-259): 8.21e-18: 86.4: 17.00		SMUF1_HUMAN (2220-2607): 1.5e-116: 391: 19.70
+	Hs
		125310 WDR5_HUMAN (1-103): 1.25e-14: 75.4: 13.76		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		1056609 FBXW7_HUMAN (1-149): 4.03e-22: 99.3: 7.38		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Hs
		1056577 A16L1_HUMAN (65-330): 1.22e-16: 82.9: 15.39		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Mm
		103551 A16L1_MOUSE (13-330): 1.42e-15: 79.4: 16.31		TRIPC_MOUSE (5-1083): 1.48e-57: 224: 13.54
+	Hs
		983153 A16L1_HUMAN (65-330): 1.22e-16: 82.9: 15.39		UBE3A_HUMAN (2406-2607): 5.17e-25: 116: 34.95
+	Hs
		903156 WDR5_HUMAN (1-103): 1.25e-14: 75.4: 13.76		UBE3A_HUMAN (2406-2607): 5.17e-25: 116: 34.95
+	Hs
		1146620 A16L1_HUMAN (65-330): 1.22e-16: 82.9: 15.39		ANR44_HUMAN (1-265): 2.58e-14: 81.6: 9.52
+	Mm
		71296 A16L1_MOUSE (13-330): 1.42e-15: 79.4: 16.31		ANR44_MOUSE (1-265): 1.25e-13: 79.3: 10.23