HitPredict

Interactor 1: SKAP1 (Q86WV1)
Src kinase-associated phosphoprotein 1 (Src family-associated phosphoprotein 1) (Src kinase-associated phosphoprotein of 55 kDa) (SKAP-55) (pp55)
Gene: SKAP1

Interactor 2: NEK1 (Q96PY6)
Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55)
Gene: NEK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 359 Hs			1 1258
+	Hs
		269528 SKAP2_HUMAN (6-356): 5.24e-102: 306: 43.58		KCC2D_HUMAN (2-281): 1.99e-112: 363: 28.82
+	Hs
		851570 SKAP1_HUMAN (1-359): 2.76e-125: 366: 100.00		NEK4_HUMAN (1-266): 1.31e-78: 279: 50.56
+	Hs
		149443 PKHA6_HUMAN (71-293): 1.58e-35: 139: 16.59		CTRO_HUMAN (2-1006): 2.42e-143: 481: 16.04
+	Hs
		149286 PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56		CTRO_HUMAN (2-1006): 2.42e-143: 481: 16.04
+	Hs
		1137906 PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56		MRCKA_HUMAN (2-901): 2.99e-144: 480: 19.19
+	Hs
		1035207 PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56		ROCK1_HUMAN (2-1044): 4.42e-142: 467: 15.73
+	Hs
		254513 PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56		ROCK2_HUMAN (2-1006): 3.93e-141: 465: 17.30
+	Hs
		647959 PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56		MARK3_HUMAN (3-645): 1.72e-137: 439: 17.22
+	Hs
		296421 PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56		STK10_HUMAN (2-900): 9.08e-129: 422: 17.29
+	Hs
		1038924 PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56		KCC2B_HUMAN (2-571): 7.98e-131: 418: 18.90
+	Hs
		986403 BTK_HUMAN (105-356): 8.02e-32: 128: 12.72		KS6B2_HUMAN (4-347): 1.84e-121: 386: 25.62
+	Hs
		681860 CYH1_HUMAN (77-231): 5.6e-33: 128: 17.22		AKT1_HUMAN (1-316): 5.31e-119: 380: 27.41
+	Hs
		682210 PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56		AKT2_HUMAN (1-320): 4.57e-123: 391: 26.87
+	Hs
		1039174 MYO10_HUMAN (108-245): 2.15e-32: 130: 23.45		KCC2D_HUMAN (2-281): 1.99e-112: 363: 28.82
+	Hs
		682023 PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56		AKT1_HUMAN (1-316): 5.31e-119: 380: 27.41
+	Hs
		1039170 PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56		KCC2D_HUMAN (2-281): 1.99e-112: 363: 28.82
+	Hs
		851682 PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56		NEK4_HUMAN (1-266): 1.31e-78: 279: 50.56
+	Hs
		1153391 PKHA7_HUMAN (57-290): 7.79e-35: 137: 14.02		NEK6_HUMAN (8-267): 7.24e-52: 187: 36.84
+	Hs
		1071703 PKHA5_HUMAN (79-294): 1.89e-32: 130: 16.20		KS6A2_HUMAN (8-274): 4.38e-19: 95.5: 25.45
+	Hs
		850712 PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56		KS6A3_HUMAN (8-258): 1.43e-16: 87.4: 25.86