Interactor 1: STING (Q86WV6)
Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173)
Gene: STING1

Interactor 2: STING (Q86WV6)
Stimulator of interferon genes protein (hSTING) (Endoplasmic reticulum interferon stimulator) (ERIS) (Mediator of IRF3 activation) (hMITA) (Transmembrane protein 173)
Gene: STING1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 30018345, 22312431, 33086059, 32678307, 35765167, 21074459, 18818105, 19433799, 22728658, 22728659, 22728660, 30405246, 30842659, 23542348
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, comigration in sds page, comigration in non denaturing gel electrophoresis, x-ray crystallography, molecular sieving, dynamic light scattering, 3D electron microscopy
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains TMEM173~TMEM173
Common GO terms GO:0000045 - autophagosome assembly
GO:0000139 - Golgi membrane
GO:0000421 - autophagosome membrane
GO:0002218 - activation of innate immune response
GO:0002221 - pattern recognition receptor signaling pathway
and 42 others

more...

Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 379
Hs

1 379
+ Mm
+ Gg

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024