HitPredict

Interactor 1: RHOD (O00212)
Rho-related GTP-binding protein RhoD (Rho-related protein HP1) (RhoHP1)
Gene: RHOD

Interactor 2: MRCKA (Q5VT25)
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 210 Hs			1 1732
+	Hs
		1137908 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		MRCKA_HUMAN (1-1732): 0: 1615: 100.00
+	Hs
		925344 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		MRCKA_HUMAN (1-1732): 0: 1615: 100.00
+	Hs
		1335421 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		MRCKB_HUMAN (1-1731): 0: 1417: 60.38
+	Hs
		120735 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		MRCKB_HUMAN (1-1731): 0: 1417: 60.38
+	Hs
		925766 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		MRCKB_HUMAN (1-1731): 0: 1417: 60.38
+	Hs
		925356 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		MRCKG_HUMAN (4-1712): 0: 1145: 39.90
+	Hs
		925229 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		DMPK_HUMAN (1-539): 8.55e-141: 451: 48.17
+	Hs
		148653 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43
+	Mm
		823530 RAC1_MOUSE (15-202): 3.58e-77: 231: 50.00		CTRO_MOUSE (4-1025): 1.07e-120: 424: 23.41
+	Mm
		823529 CDC42_MOUSE (15-202): 1.05e-76: 230: 44.68		CTRO_MOUSE (4-1025): 1.07e-120: 424: 23.41
+	Hs
		681775 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Mm
		925783 RAC1_MOUSE (15-202): 3.58e-77: 231: 50.00		TNIK_MOUSE (53-700): 2.14e-94: 337: 15.88
+	Dm
		116376 RHO1_DROME (19-200): 2.84e-76: 229: 53.30		M9PI41_DROME (339-1478): 1.41e-80: 297: 13.08
+	Hs
		254515 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07
+	Hs
		120238 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07
+	Hs
		254468 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07
+	Hs
		1035208 RHOF_HUMAN (7-193): 1.18e-78: 236: 54.26		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28
+	Dm
		816384 RHO1_DROME (19-200): 2.84e-76: 229: 53.30		Q961D4_DROME (391-1130): 1.08e-21: 105: 12.02
+	Hs
		120420 RHOD_HUMAN (1-210): 1.91e-77: 232: 100.00		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28
+	Hs
		925253 RAC1_HUMAN (15-202): 3.58e-77: 231: 50.00		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28