HitPredict

Interactor 1: VRK2 (Q86Y07)
Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2)
Gene: VRK2

Interactor 2: MIRO2 (Q8IXI1)
Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2)
Gene: RHOT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	32877691
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 508 Hs			1 618
+	Hs
		545478 VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00		RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69
+	Hs
		892467 VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00		RAC3_HUMAN (3-168): 9.6e-79: 249: 27.22
+	Hs
		545461 MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73		RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69
+	Hs
		894184 VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00		CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54
+	Hs
		1070279 VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00		RAB35_HUMAN (5-168): 3.51e-76: 242: 24.70
+	Hs
		892447 MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73		RAC3_HUMAN (3-168): 9.6e-79: 249: 27.22
+	Hs
		951129 VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00		RHOG_HUMAN (3-170): 1.68e-74: 238: 27.47
+	Hs
		894157 MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73		CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54
+	Hs
		925409 VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00		RAC1_HUMAN (3-181): 3.15e-74: 237: 26.43
+	Hs
		914187 VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00		RB11A_HUMAN (416-572): 8.23e-22: 96.2: 20.37
+	Hs
		914159 MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73		RB11A_HUMAN (416-572): 8.23e-22: 96.2: 20.37
+	Hs
		900655 VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00		RHOA_HUMAN (6-168): 1.74e-11: 65.5: 28.25
+	Hs
		1205070 VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00		RHOF_HUMAN (2-167): 3.37e-11: 65.1: 26.67
+	Hs
		436388 VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00		RHOC_HUMAN (6-168): 3.86e-11: 64.3: 28.25
+	Hs
		120520 VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00		RHOD_HUMAN (3-167): 1.27e-10: 63.2: 28.89
+	Hs
		915778 MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73		RHOB_HUMAN (6-168): 4.57e-13: 70.1: 29.38
+	Hs
		900617 MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73		RHOA_HUMAN (6-168): 1.74e-11: 65.5: 28.25
+	Hs
		436371 MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73		RHOC_HUMAN (6-168): 3.86e-11: 64.3: 28.25
+	Hs
		120505 MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73		RHOD_HUMAN (3-167): 1.27e-10: 63.2: 28.89
+	Hs
		564584 MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73		RHOQ_HUMAN (5-169): 2.02e-10: 62.8: 26.26