HitPredict

Interactor 1: DZIP3 (Q86Y13)
E3 ubiquitin-protein ligase DZIP3 (EC 2.3.2.27) (DAZ-interacting protein 3) (RING-type E3 ubiquitin transferase DZIP3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138)
Gene: DZIP3

Interactor 2: UB2E2 (Q96LR5)
Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2)
Gene: UBE2E2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.885

Property	Details
Experiments	21516116, 19549727, 31515488, 29892012
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1208 Hs			1 201
+	Hs
		1205108 DZIP3_HUMAN (1-1208): 0: 1250: 100.00		UB2E3_HUMAN (1-201): 6.37e-85: 251: 79.71
+	Hs
		1205159 DZIP3_HUMAN (1-1208): 0: 1250: 100.00		UB2D4_HUMAN (55-200): 9.37e-83: 243: 63.01
+	Hs
		919775 DZIP3_HUMAN (1-1208): 0: 1250: 100.00		UB2D2_HUMAN (55-200): 2.8e-82: 242: 64.38
+	Hs
		849362 DZIP3_HUMAN (1-1208): 0: 1250: 100.00		UB2D1_HUMAN (55-200): 1.23e-81: 240: 61.64
+	Hs
		851839 DZIP3_HUMAN (1-1208): 0: 1250: 100.00		UB2E1_HUMAN (28-201): 6.5e-80: 238: 89.71
+	Hs
		895840 DZIP3_HUMAN (1-1208): 0: 1250: 100.00		UB2D3_HUMAN (55-200): 1.28e-80: 238: 63.70
+	Hs
		896485 DZIP3_HUMAN (1-1208): 0: 1250: 100.00		UBE2N_HUMAN (53-200): 2.86e-70: 212: 45.27
+	Hs
		196372 PJA2_HUMAN (601-1207): 1.64e-59: 220: 14.47		UB2D4_HUMAN (55-200): 9.37e-83: 243: 63.01
+	Hs
		196294 PJA2_HUMAN (601-1207): 1.64e-59: 220: 14.47		UB2D2_HUMAN (55-200): 2.8e-82: 242: 64.38
+	Hs
		196282 PJA2_HUMAN (601-1207): 1.64e-59: 220: 14.47		UB2D1_HUMAN (55-200): 1.23e-81: 240: 61.64
+	Hs
		196289 PJA2_HUMAN (601-1207): 1.64e-59: 220: 14.47		UB2D3_HUMAN (55-200): 1.28e-80: 238: 63.70
+	Hs
		196290 PJA2_HUMAN (601-1207): 1.64e-59: 220: 14.47		UBE2N_HUMAN (53-200): 2.86e-70: 212: 45.27
+	Hs
		865068 TTC3_HUMAN (703-1207): 1.23e-42: 173: 19.15		UB2E3_HUMAN (1-201): 6.37e-85: 251: 79.71
+	Hs
		865028 TTC3_HUMAN (703-1207): 1.23e-42: 173: 19.15		UB2D2_HUMAN (55-200): 2.8e-82: 242: 64.38
+	Hs
		828999 DCTN1_HUMAN (639-961): 5.05e-41: 167: 15.84		UBE2A_HUMAN (54-198): 1.67e-70: 212: 35.86
+	Hs
		919759 ARK2C_HUMAN (1008-1191): 3.26e-29: 122: 17.74		UB2D2_HUMAN (55-200): 2.8e-82: 242: 64.38
+	Hs
		849350 ARK2C_HUMAN (1008-1191): 3.26e-29: 122: 17.74		UB2D1_HUMAN (55-200): 1.23e-81: 240: 61.64
+	Hs
		851829 ARK2C_HUMAN (1008-1191): 3.26e-29: 122: 17.74		UB2E1_HUMAN (28-201): 6.5e-80: 238: 89.71
+	Hs
		895822 ARK2C_HUMAN (1008-1191): 3.26e-29: 122: 17.74		UB2D3_HUMAN (55-200): 1.28e-80: 238: 63.70
+	Hs
		896474 ARK2C_HUMAN (1008-1191): 3.26e-29: 122: 17.74		UBE2N_HUMAN (53-200): 2.86e-70: 212: 45.27