HitPredict

Interactor 1: LRC33 (Q86YC3)
Transforming growth factor beta activator LRRC33 (Leucine-rich repeat-containing protein 33) (Negative regulator of reactive oxygen species)
Gene: NRROS

Interactor 2: LIGO1 (Q96FE5)
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (Leucine-rich repeat and immunoglobulin domain-containing protein 1) (Leucine-rich repeat neuronal protein 1) (Leucine-rich repeat neuronal protein 6A)
Gene: LINGO1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LRR_1~LRR_8, LRR_6~LRR_8, I-set~LRR_8, LRR_8~LRR_8
Common GO terms	GO:0005615 - extracellular space GO:0005886 - plasma membrane GO:0031012 - extracellular matrix
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 692 Hs			1 620
+	At
		1323635 GSO2_ARATH (5-638): 5.82e-79: 276: 18.45		EMS1_ARATH (13-441): 3.84e-73: 257: 16.23
+	At
		84732 Y4361_ARATH (6-626): 5.62e-79: 275: 19.00		PXC3_ARATH (93-472): 3.33e-54: 200: 16.84
+	At
		1114706 PXL1_ARATH (6-510): 5.77e-64: 231: 20.35		ERECT_ARATH (32-441): 4.94e-67: 238: 15.21
+	At
		1338062 RGI1_ARATH (217-691): 4.99e-57: 211: 14.69		EMS1_ARATH (13-441): 3.84e-73: 257: 16.23
+	At
		1352203 BRL2_ARATH (6-473): 7.23e-63: 228: 18.27		Y1723_ARATH (25-441): 9.26e-63: 226: 15.59
+	At
		1378334 BRL2_ARATH (6-473): 7.23e-63: 228: 18.27		BRL2_ARATH (25-456): 4.5e-62: 224: 14.93
+	Zm
		19443 A0A1D6HD42_MAIZE (250-691): 5.86e-57: 211: 17.35		A0A1D6HD42_MAIZE (36-441): 4.39e-67: 239: 17.55
+	At
		1338065 BRL2_ARATH (6-473): 7.23e-63: 228: 18.27		RGI1_ARATH (49-486): 6.58e-61: 221: 15.42
+	At
		1338953 BRL2_ARATH (6-473): 7.23e-63: 228: 18.27		Y1571_ARATH (1-316): 7.38e-59: 215: 20.31
+	At
		1325020 PXL1_ARATH (6-510): 5.77e-64: 231: 20.35		PXL1_ARATH (1-289): 1.36e-57: 211: 16.83
+	At
		1114726 BRL1_ARATH (7-463): 7.79e-52: 196: 17.58		ERECT_ARATH (32-441): 4.94e-67: 238: 15.21
+	At
		1324089 BRL1_ARATH (7-463): 7.79e-52: 196: 17.58		FLS2_ARATH (45-443): 5.1e-64: 230: 18.41
+	At
		84451 Y4361_ARATH (6-626): 5.62e-79: 275: 19.00		GSO1_ARATH (149-445): 4.66e-34: 140: 17.51
+	At
		84509 BRL2_ARATH (6-473): 7.23e-63: 228: 18.27		GSO1_ARATH (149-445): 4.66e-34: 140: 17.51
+	At
		84728 Y4361_ARATH (6-626): 5.62e-79: 275: 19.00		ERL1_ARATH (212-443): 8.11e-18: 89.7: 16.39
+	At
		85103 RGI2_ARATH (121-691): 3.78e-74: 261: 18.72		ERL2_ARATH (224-443): 3.14e-16: 84.7: 16.22
+	At
		84511 BRL1_ARATH (7-463): 7.79e-52: 196: 17.58		GSO1_ARATH (149-445): 4.66e-34: 140: 17.51
+	At
		1167645 BRL1_ARATH (7-463): 7.79e-52: 196: 17.58		ERL2_ARATH (224-443): 3.14e-16: 84.7: 16.22