HitPredict

Interactor 1: MD12L (Q86YW9)
Mediator of RNA polymerase II transcription subunit 12-like protein (Mediator complex subunit 12-like protein) (Thyroid hormone receptor-associated-like protein) (Trinucleotide repeat-containing gene 11 protein-like)
Gene: MED12L

Interactor 2: MED4 (Q9NPJ6)
Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36)
Gene: MED4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	24981860, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003713 - transcription coactivator activity GO:0016592 - mediator complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 2145 Hs			1 270
+	Hs
		1274349 MED12_HUMAN (1-2036): 0: 2238: 58.62		MED4_HUMAN (1-258): 3.31e-135: 384: 100.00
+	Hs
		1319414 WDR33_HUMAN (1582-2011): 1.04e-17: 92.7: 9.79		MED4_HUMAN (1-258): 3.31e-135: 384: 100.00
+	Hs
		1167126 MCAF1_HUMAN (1570-2036): 1.45e-13: 78.8: 7.55		MED4_HUMAN (1-258): 3.31e-135: 384: 100.00