HitPredict

Interactor 1: MD12L (Q86YW9)
Mediator of RNA polymerase II transcription subunit 12-like protein (Mediator complex subunit 12-like protein) (Thyroid hormone receptor-associated-like protein) (Trinucleotide repeat-containing gene 11 protein-like)
Gene: MED12L

Interactor 2: MED13 (Q9UHV7)
Mediator of RNA polymerase II transcription subunit 13 (Activator-recruited cofactor 250 kDa component) (ARC250) (Mediator complex subunit 13) (Thyroid hormone receptor-associated protein 1) (Thyroid hormone receptor-associated protein complex 240 kDa component) (Trap240) (Vitamin D3 receptor-interacting protein complex component DRIP250) (DRIP250)
Gene: MED13

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	29568061, 24981860
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003713 - transcription coactivator activity GO:0016592 - mediator complex GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 2145 Hs			1 2174
+	Hs
		1174756 MD12L_HUMAN (1-2145): 0: 2524: 100.00		MD13L_HUMAN (2-2174): 0: 3190: 51.68
+	Hs
		1274360 MED12_HUMAN (1-2036): 0: 2238: 58.62		MED13_HUMAN (1-2174): 0: 3460: 100.00
+	Hs
		1174762 MED12_HUMAN (1-2036): 0: 2238: 58.62		MD13L_HUMAN (2-2174): 0: 3190: 51.68
+	Hs
		256835 T22D2_HUMAN (1893-2141): 1.99e-09: 64.9: 13.46		MED13_HUMAN (1-2174): 0: 3460: 100.00
+	Dm
		1182310 MED12_DROME (10-207): 1.64e-70: 266: 51.01		MED13_DROME (776-947): 6.01e-50: 198: 25.11