HitPredict

Interactor 1: APC2 (Q874R3)
Anaphase-promoting complex subunit 2 (20S cyclosome/APC complex protein apc2)
Gene: APC2

Interactor 2: APC11 (Q9UT86)
Anaphase-promoting complex subunit 11 (20S cyclosome/APC complex protein apc11)
Gene: APC11

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	26771498, 16950791
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ANAPC2~zf-ANAPC11, Cullin~zf-ANAPC11
Common GO terms	GO:0005634 - nucleus GO:0005680 - anaphase-promoting complex GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 681 Sp			1 94
+	At
		1275966 CUL3A_ARATH (109-671): 9.21e-173: 513: 14.62		RBX1A_ARATH (2-85): 7.01e-28: 99.4: 32.58
+	At
		1275962 CUL3B_ARATH (107-671): 1.91e-170: 506: 14.45		RBX1A_ARATH (2-85): 7.01e-28: 99.4: 32.58
+	Hs
		1348495 ANC2_HUMAN (132-680): 9.25e-167: 500: 29.90		APC11_HUMAN (1-85): 1.32e-30: 105: 50.59
+	Dm
		1180483 Q9W1E5_DROME (106-680): 6.69e-161: 484: 27.66		Q7KA43_DROME (1-83): 4.69e-30: 103: 48.19
+	At
		1210831 APC2_ARATH (138-681): 2.62e-149: 456: 28.60		APC11_ARATH (1-85): 2.45e-32: 109: 55.29
+	Hs
		921253 CUL3_HUMAN (109-671): 2.55e-151: 459: 13.79		RBX1_HUMAN (2-85): 8.51e-29: 101: 31.46
+	Hs
		1042735 CUL3_HUMAN (109-671): 2.55e-151: 459: 13.79		RBX2_HUMAN (3-85): 7.9e-24: 88.7: 32.94
+	Hs
		296909 CUL3_HUMAN (109-671): 2.55e-151: 459: 13.79		LTN1_HUMAN (10-81): 2.52e-13: 65.5: 26.32
+	Hs
		921255 CUL4B_HUMAN (43-670): 1.01e-134: 420: 14.79		RBX1_HUMAN (2-85): 8.51e-29: 101: 31.46
+	Dm
		1124381 Q5BI50_DROME (109-670): 5.38e-136: 420: 14.19		RBX1A_DROME (2-85): 2.11e-28: 100: 31.46
+	Dm
		1213855 Q8IP45_DROME (107-671): 1.88e-134: 420: 12.23		RBX1A_DROME (2-85): 2.11e-28: 100: 31.46
+	Mm
		921499 CUL4A_MOUSE (37-670): 4.78e-136: 419: 14.66		RBX1_MOUSE (2-85): 8.51e-29: 101: 31.46
+	Dm
		1213836 Q8IP45_DROME (107-671): 1.88e-134: 420: 12.23		RBX1B_DROME (2-85): 8.38e-27: 96.7: 34.09
+	Mm
		56790 CUL4B_MOUSE (43-670): 1.71e-132: 415: 14.79		RBX1_MOUSE (2-85): 8.51e-29: 101: 31.46
+	Hs
		921254 CUL4A_HUMAN (41-670): 1.06e-133: 413: 14.60		RBX1_HUMAN (2-85): 8.51e-29: 101: 31.46
+	Hs
		1043627 CUL4B_HUMAN (43-670): 1.01e-134: 420: 14.79		RBX2_HUMAN (3-85): 7.9e-24: 88.7: 32.94
+	Mm
		1111822 CUL4A_MOUSE (37-670): 4.78e-136: 419: 14.66		RBX2_MOUSE (3-85): 7.08e-24: 89: 32.94
+	At
		1228140 CUL4_ARATH (103-671): 3.25e-131: 407: 15.40		RBX1A_ARATH (2-85): 7.01e-28: 99.4: 32.58
+	Hs
		1043275 CUL4A_HUMAN (41-670): 1.06e-133: 413: 14.60		RBX2_HUMAN (3-85): 7.9e-24: 88.7: 32.94
+	Hs
		921251 CUL1_HUMAN (108-674): 5.48e-127: 396: 13.52		RBX1_HUMAN (2-85): 8.51e-29: 101: 31.46