HitPredict

Interactor 1: TRI65 (Q8BFW4)
E3 ubiquitin-protein ligase TRIM65 (EC 2.3.2.27) (Tripartite motif-containing protein 65)
Gene: Trim65

Interactor 2: NLRP3 (Q8R4B8)
NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Cold autoinflammatory syndrome 1 protein homolog) (Cryopyrin) (Mast cell maturation-associated-inducible protein 1) (PYRIN-containing APAF1-like protein 1)
Gene: NLRP3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34512673
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 522 Mm			1 1033
+	Mm
		1112452 Q3UCL2_MOUSE (3-505): 2.07e-120: 363: 20.62		NLRP3_MOUSE (1-1033): 0: 895: 100.00
+	Hs
		1162050 TRI65_HUMAN (1-520): 4.75e-117: 356: 63.85		NLRP3_HUMAN (1-1033): 0: 859: 82.43
+	Mm
		1194997 TRI50_MOUSE (5-515): 6.87e-99: 308: 19.42		NLRP3_MOUSE (1-1033): 0: 895: 100.00
+	Mm
		1246775 TRI31_MOUSE (1-504): 4.81e-96: 302: 20.04		NLRP3_MOUSE (1-1033): 0: 895: 100.00
+	Mm
		1207374 TRI14_MOUSE (82-506): 1.84e-92: 291: 20.64		NLRP3_MOUSE (1-1033): 0: 895: 100.00
+	Hs
		1204904 TRI50_HUMAN (2-506): 3.55e-97: 304: 19.84		NLRP3_HUMAN (1-1033): 0: 859: 82.43
+	Hs
		183332 MEFV_HUMAN (40-507): 1.52e-88: 290: 16.77		NLRP3_HUMAN (1-1033): 0: 859: 82.43
+	Hs
		537077 TRI27_HUMAN (1-510): 2.71e-120: 365: 19.24		NOD2_HUMAN (796-1032): 2.65e-20: 99.4: 25.32
+	Hs
		1162057 TRI65_HUMAN (1-520): 4.75e-117: 356: 63.85		NLRP1_HUMAN (2-186): 1.66e-17: 90.5: 18.42
+	Hs
		1223391 TRI22_HUMAN (8-505): 4.48e-107: 330: 18.42		NOD2_HUMAN (796-1032): 2.65e-20: 99.4: 25.32
+	Hs
		1149907 TRI68_HUMAN (9-509): 6.16e-109: 335: 17.96		NLRP1_HUMAN (2-186): 1.66e-17: 90.5: 18.42
+	Hs
		1162063 TRI65_HUMAN (1-520): 4.75e-117: 356: 63.85		NLRC4_HUMAN (582-844): 1.45e-09: 64.3: 13.59
+	Hs
		183339 MEFV_HUMAN (40-507): 1.52e-88: 290: 16.77		NALP2_HUMAN (716-1031): 6.87e-26: 117: 27.67
+	Hs
		886400 TRI25_HUMAN (1-504): 6.37e-94: 300: 21.35		NAL12_HUMAN (531-854): 1.24e-22: 107: 24.85
+	Hs
		135016 TRI38_HUMAN (2-507): 3.77e-101: 314: 19.27		NLRP6_HUMAN (772-1030): 3.44e-18: 92.5: 25.28
+	Hs
		702498 TRI22_HUMAN (8-505): 4.48e-107: 330: 18.42		C2TA_HUMAN (771-1028): 6.92e-13: 75.1: 16.19
+	Hs
		1204907 TRI50_HUMAN (2-506): 3.55e-97: 304: 19.84		NOD2_HUMAN (796-1032): 2.65e-20: 99.4: 25.32
+	Hs
		1052765 TRI25_HUMAN (1-504): 6.37e-94: 300: 21.35		NLRP1_HUMAN (2-186): 1.66e-17: 90.5: 18.42
+	Hs
		183335 MEFV_HUMAN (40-507): 1.52e-88: 290: 16.77		NLRP1_HUMAN (2-186): 1.66e-17: 90.5: 18.42
+	Hs
		1103710 TR16L_HUMAN (185-512): 8.61e-18: 86.7: 24.71		NLRP1_HUMAN (2-186): 1.66e-17: 90.5: 18.42