HitPredict

Interactor 1: FBXW8 (Q8BIA4)
F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8)
Gene: FBXW8

Interactor 2: SKP1 (Q9WTX5)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1)
Gene: SKP1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	16880526
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	F-box-like~Skp1
Common GO terms	GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0019005 - SCF ubiquitin ligase complex GO:0031467 - Cul7-RING ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 598 Mm			1 163
+	Hs
		928984 FBXW8_HUMAN (1-598): 6.44e-115: 356: 74.75		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Mm
		1112932 FBW1A_MOUSE (287-587): 9.72e-65: 224: 13.06		SKP1_MOUSE (1-163): 3.56e-91: 263: 100.00
+	Hs
		929110 FBW1B_HUMAN (287-587): 2.59e-64: 222: 12.74		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Mm
		1131317 FBW1B_MOUSE (287-587): 4.44e-64: 221: 12.74		SKP1_MOUSE (1-163): 3.56e-91: 263: 100.00
+	Ce
		105479 SEL10_CAEEL (284-589): 2.91e-71: 242: 13.33		SKR1_CAEEL (4-162): 1.3e-80: 237: 70.81
+	Dm
		218244 O44382_DROME (285-587): 3.19e-65: 223: 13.75		O77430_DROME (1-163): 3.96e-82: 240: 76.07
+	Dm
		285012 Q9VDE3_DROME (285-587): 6.13e-65: 222: 14.06		O77430_DROME (1-163): 3.96e-82: 240: 76.07
+	Sp
		953229 POF1_SCHPO (162-470): 2.85e-68: 234: 14.10		SKP1_SCHPO (1-163): 1.77e-74: 221: 56.36
+	Dm
		1180601 Q9VDE3_DROME (285-587): 6.13e-65: 222: 14.06		Q7KJ69_DROME (1-163): 1.72e-76: 226: 67.49
+	Hs
		245588 TBL1X_HUMAN (49-376): 3.6e-50: 184: 10.29		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Dm
		285042 FBXW7_DROME (372-589): 1.89e-51: 193: 17.27		O77430_DROME (1-163): 3.96e-82: 240: 76.07
+	Dm
		1363661 Q9VDE3_DROME (285-587): 6.13e-65: 222: 14.06		Q9VWC4_DROME (2-153): 2.29e-65: 198: 56.86
+	Mm
		1257397 FBXW7_MOUSE (418-593): 9.74e-38: 150: 16.20		SKP1_MOUSE (1-163): 3.56e-91: 263: 100.00
+	Hs
		929021 FBXW7_HUMAN (418-593): 1.6e-37: 150: 16.20		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Sp
		144900 POP2_SCHPO (336-588): 2.7e-42: 164: 12.89		SKP1_SCHPO (1-163): 1.77e-74: 221: 56.36
+	Sp
		953235 POP1_SCHPO (336-581): 4.09e-36: 146: 11.82		SKP1_SCHPO (1-163): 1.77e-74: 221: 56.36
+	Sc
		759309 MET30_YEAST (373-563): 2.2e-42: 163: 13.02		SKP1_YEAST (4-163): 2.12e-66: 202: 42.63
+	Ce
		105997 LIN23_CAEEL (432-590): 6.66e-31: 130: 19.38		G5EDD8_CAEEL (4-162): 4.74e-67: 203: 60.25
+	Sp
		1000009 POF11_SCHPO (441-588): 9.43e-21: 97.7: 17.45		SKP1_SCHPO (1-163): 1.77e-74: 221: 56.36
+	Sc
		431143 CDC4_YEAST (470-597): 2.27e-16: 84.7: 16.55		SKP1_YEAST (4-163): 2.12e-66: 202: 42.63