HitPredict

Interactor 1: TCAM2 (Q8BJQ4)
TIR domain-containing adapter molecule 2 (TICAM-2) (TRIF-related adapter molecule) (Toll/interleukin-1 receptor domain-containing protein)
Gene: Ticam2

Interactor 2: TLR4 (Q9QUK6)
Toll-like receptor 4 (CD antigen CD284)
Gene: TLR4

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 0.60 0.674

The method score is based on:

Property Details
Experiments 19378012, 18222170, 18927610, 23023391
Identification Methods protein complementation assay, anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001891 - phagocytic cup
GO:0005769 - early endosome
GO:0005886 - plasma membrane
GO:0006909 - phagocytosis
GO:0006954 - inflammatory response
and 9 others

more...
Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 232
Mm

1 835
+ Mm
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024