HitPredict

Interactor 1: ELMO1 (Q8BPU7)
Engulfment and cell motility protein 1 (Protein ced-12 homolog)
Gene: ELMO1

Interactor 2: DOCK1 (Q8BUR4)
Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)
Gene: DOCK1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	20829512, 15102471
Identification Methods	anti tag coimmunoprecipitation, two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DOCK_N~PH_12
Common GO terms	GO:0005085 - guanyl-nucleotide exchange factor activity GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0006909 - phagocytosis GO:0006915 - apoptotic process and 1 others more... GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 727 Mm			1 1865
+	Hs
		1050484 ELMO1_HUMAN (1-727): 0: 1067: 99.59		DOCK1_HUMAN (1-1823): 0: 2255: 96.65
+	Hs
		1050489 ELMO2_HUMAN (1-724): 0: 985: 75.45		DOCK1_HUMAN (1-1823): 0: 2255: 96.65
+	Mm
		1206593 ELMO2_MOUSE (1-724): 0: 974: 74.08		DOCK1_MOUSE (1-1819): 0: 2266: 100.00
+	Mm
		1207312 ELMO3_MOUSE (1-725): 0: 925: 52.47		DOCK1_MOUSE (1-1819): 0: 2266: 100.00
+	Hs
		1050487 ELMO3_HUMAN (1-727): 0: 934: 51.51		DOCK1_HUMAN (1-1823): 0: 2255: 96.65
+	Hs
		1267020 ELMO1_HUMAN (1-727): 0: 1067: 99.59		DOCK2_HUMAN (1-1804): 0: 2037: 59.45
+	Mm
		1207130 ELMO1_MOUSE (1-727): 0: 1067: 100.00		DOCK2_MOUSE (1-1804): 0: 1994: 59.10
+	Hs
		1267024 ELMO1_HUMAN (1-727): 0: 1067: 99.59		DOCK5_HUMAN (1-1830): 0: 1993: 63.02
+	Hs
		1267934 ELMO2_HUMAN (1-724): 0: 985: 75.45		DOCK2_HUMAN (1-1804): 0: 2037: 59.45
+	Hs
		1295265 ELMO2_HUMAN (1-724): 0: 985: 75.45		DOCK5_HUMAN (1-1830): 0: 1993: 63.02
+	Hs
		1285559 ELMO3_HUMAN (1-727): 0: 934: 51.51		DOCK5_HUMAN (1-1830): 0: 1993: 63.02
+	Hs
		1224220 ELMO1_HUMAN (1-727): 0: 1067: 99.59		DOCK3_HUMAN (4-1860): 0: 1839: 36.47
+	Hs
		1230987 ELMO1_HUMAN (1-727): 0: 1067: 99.59		DOCK4_HUMAN (4-1862): 0: 1825: 36.34
+	Hs
		1224227 ELMO2_HUMAN (1-724): 0: 985: 75.45		DOCK3_HUMAN (4-1860): 0: 1839: 36.47
+	Hs
		1230992 ELMO2_HUMAN (1-724): 0: 985: 75.45		DOCK4_HUMAN (4-1862): 0: 1825: 36.34
+	Hs
		1061751 ELMO2_HUMAN (1-724): 0: 985: 75.45		Q149N5_HUMAN (4-1862): 0: 1795: 35.41
+	Hs
		1224225 ELMO3_HUMAN (1-727): 0: 934: 51.51		DOCK3_HUMAN (4-1860): 0: 1839: 36.47
+	Hs
		1230990 ELMO3_HUMAN (1-727): 0: 934: 51.51		DOCK4_HUMAN (4-1862): 0: 1825: 36.34
+	Dm
		1362934 Q9VKB2_DROME (5-725): 0: 835: 45.92		Q9VCH4_DROME (1-1822): 0: 1842: 38.72
+	Dm
		81396 Q9VKB2_DROME (5-725): 0: 835: 45.92		B7Z0R2_DROME (4-1764): 0: 1684: 36.01