HitPredict

Interactor 1: Q8BTS0 (Q8BTS0)
Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5)
Gene: Ddx5

Interactor 2: SMAD3 (Q8BUN5)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (mMad3) (SMAD family member 3) (SMAD 3) (Smad3)
Gene: SMAD3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15464984
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005737 - cytoplasm GO:0019899 - enzyme binding GO:0070412 - R-SMAD binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 615 Mm			1 425
+	Hs
		571401 DDX5_HUMAN (1-615): 0: 609: 98.86		SMAD3_HUMAN (1-425): 0: 636: 100.00
+	Mm
		1143947 Q8BTS0_MOUSE (1-615): 0: 614: 100.00		SMAD2_MOUSE (1-425): 0: 591: 83.73
+	Mm
		936615 Q8BTS0_MOUSE (1-615): 0: 614: 100.00		SMAD1_MOUSE (1-425): 0: 560: 59.87
+	Hs
		571470 DDX5_HUMAN (1-615): 0: 609: 98.86		SMAD1_HUMAN (1-425): 0: 559: 60.09
+	Hs
		571568 DDX5_HUMAN (1-615): 0: 609: 98.86		SMAD5_HUMAN (1-425): 0: 556: 59.83
+	Hs
		133977 DDX3X_HUMAN (3-478): 1.97e-148: 445: 38.66		SMAD3_HUMAN (1-425): 0: 636: 100.00
+	Hs
		181693 DDX3Y_HUMAN (3-485): 3.4e-148: 445: 37.40		SMAD3_HUMAN (1-425): 0: 636: 100.00
+	Hs
		181701 DDX3Y_HUMAN (3-485): 3.4e-148: 445: 37.40		SMAD2_HUMAN (1-425): 0: 589: 83.73
+	Mm
		956548 Q8BTS0_MOUSE (1-615): 0: 614: 100.00		SMAD4_MOUSE (23-414): 2.27e-119: 360: 32.88
+	Mm
		192488 Q8BTS0_MOUSE (1-615): 0: 614: 100.00		SMAD7_MOUSE (28-403): 8.69e-99: 303: 27.06