HitPredict

Interactor 1: TRI14 (Q8BVW3)
Tripartite motif-containing protein 14 (PU.1-binding protein)
Gene: Trim14

Interactor 2: NLRP3 (Q8R4B8)
NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Cold autoinflammatory syndrome 1 protein homolog) (Cryopyrin) (Mast cell maturation-associated-inducible protein 1) (PYRIN-containing APAF1-like protein 1)
Gene: NLRP3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31999304
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0006954 - inflammatory response GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 440 Mm			1 1033
+	Mm
		1112452 Q3UCL2_MOUSE (14-440): 6.46e-117: 351: 19.63		NLRP3_MOUSE (1-1033): 0: 895: 100.00
+	Mm
		1194997 TRI50_MOUSE (3-440): 3.1e-99: 307: 22.47		NLRP3_MOUSE (1-1033): 0: 895: 100.00
+	Hs
		183332 MEFV_HUMAN (2-440): 1.49e-108: 339: 20.88		NLRP3_HUMAN (1-1033): 0: 859: 82.43
+	Mm
		1206333 TRI65_MOUSE (5-440): 3.22e-85: 272: 22.17		NLRP3_MOUSE (1-1033): 0: 895: 100.00
+	Mm
		1246775 TRI31_MOUSE (1-440): 4.07e-84: 268: 20.98		NLRP3_MOUSE (1-1033): 0: 895: 100.00
+	Hs
		1204904 TRI50_HUMAN (3-430): 1.64e-97: 302: 23.26		NLRP3_HUMAN (1-1033): 0: 859: 82.43
+	Hs
		1162050 TRI65_HUMAN (21-440): 2.85e-83: 266: 25.59		NLRP3_HUMAN (1-1033): 0: 859: 82.43
+	Hs
		527988 TRI14_HUMAN (1-440): 7.4e-123: 366: 77.38		RINI_HUMAN (652-1032): 1.87e-58: 210: 35.07
+	Hs
		183339 MEFV_HUMAN (2-440): 1.49e-108: 339: 20.88		NALP2_HUMAN (716-1031): 6.87e-26: 117: 27.67
+	Hs
		537077 TRI27_HUMAN (10-440): 1.39e-116: 352: 24.54		NOD2_HUMAN (796-1032): 2.65e-20: 99.4: 25.32
+	Hs
		183335 MEFV_HUMAN (2-440): 1.49e-108: 339: 20.88		NLRP1_HUMAN (2-186): 1.66e-17: 90.5: 18.42
+	Hs
		1261111 TRI41_HUMAN (7-440): 3.03e-100: 314: 23.81		NOD2_HUMAN (796-1032): 2.65e-20: 99.4: 25.32
+	Hs
		1223391 TRI22_HUMAN (12-440): 6.37e-101: 311: 19.33		NOD2_HUMAN (796-1032): 2.65e-20: 99.4: 25.32
+	Hs
		1149907 TRI68_HUMAN (16-439): 3.09e-103: 317: 20.70		NLRP1_HUMAN (2-186): 1.66e-17: 90.5: 18.42
+	Hs
		135016 TRI38_HUMAN (5-440): 6.85e-102: 313: 20.93		NLRP6_HUMAN (772-1030): 3.44e-18: 92.5: 25.28
+	Hs
		1204907 TRI50_HUMAN (3-430): 1.64e-97: 302: 23.26		NOD2_HUMAN (796-1032): 2.65e-20: 99.4: 25.32
+	Hs
		702498 TRI22_HUMAN (12-440): 6.37e-101: 311: 19.33		C2TA_HUMAN (771-1028): 6.92e-13: 75.1: 16.19
+	Hs
		1162057 TRI65_HUMAN (21-440): 2.85e-83: 266: 25.59		NLRP1_HUMAN (2-186): 1.66e-17: 90.5: 18.42
+	Hs
		1162063 TRI65_HUMAN (21-440): 2.85e-83: 266: 25.59		NLRC4_HUMAN (582-844): 1.45e-09: 64.3: 13.59
+	Hs
		1103710 TR16L_HUMAN (111-436): 7.4e-73: 234: 24.20		NLRP1_HUMAN (2-186): 1.66e-17: 90.5: 18.42