HitPredict

Interactor 1: TRI47 (Q8C0E3)
E3 ubiquitin-protein ligase TRIM47 (EC 2.3.2.27) (Tripartite motif-containing protein 47)
Gene: Trim47

Interactor 2: NLRP3 (Q8R4B8)
NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Cold autoinflammatory syndrome 1 protein homolog) (Cryopyrin) (Mast cell maturation-associated-inducible protein 1) (PYRIN-containing APAF1-like protein 1)
Gene: NLRP3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31999304
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 641 Mm			1 1033
+	Mm
		1207374 TRI14_MOUSE (169-612): 4.82e-84: 272: 21.93		NLRP3_MOUSE (1-1033): 0: 895: 100.00
+	Hs
		183332 MEFV_HUMAN (84-612): 2.1e-90: 298: 15.61		NLRP3_HUMAN (1-1033): 0: 859: 82.43
+	Mm
		1206333 TRI65_MOUSE (111-589): 1.79e-75: 252: 18.29		NLRP3_MOUSE (1-1033): 0: 895: 100.00
+	Hs
		1162050 TRI65_HUMAN (106-574): 6.26e-76: 253: 19.11		NLRP3_HUMAN (1-1033): 0: 859: 82.43
+	Mm
		1194997 TRI50_MOUSE (5-266): 1.67e-15: 81.6: 13.59		NLRP3_MOUSE (1-1033): 0: 895: 100.00
+	Mm
		1112452 Q3UCL2_MOUSE (5-258): 3.44e-15: 80.5: 13.78		NLRP3_MOUSE (1-1033): 0: 895: 100.00
+	Hs
		527988 TRI14_HUMAN (183-595): 1.04e-76: 253: 22.35		RINI_HUMAN (652-1032): 1.87e-58: 210: 35.07
+	Hs
		1261111 TRI41_HUMAN (5-590): 8.99e-102: 325: 16.12		NOD2_HUMAN (796-1032): 2.65e-20: 99.4: 25.32
+	Hs
		1103710 TR16L_HUMAN (274-583): 6.88e-109: 333: 25.63		NLRP1_HUMAN (2-186): 1.66e-17: 90.5: 18.42
+	Hs
		886400 TRI25_HUMAN (2-627): 5.09e-96: 309: 23.25		NAL12_HUMAN (531-854): 1.24e-22: 107: 24.85
+	Hs
		183339 MEFV_HUMAN (84-612): 2.1e-90: 298: 15.61		NALP2_HUMAN (716-1031): 6.87e-26: 117: 27.67
+	Hs
		1052765 TRI25_HUMAN (2-627): 5.09e-96: 309: 23.25		NLRP1_HUMAN (2-186): 1.66e-17: 90.5: 18.42
+	Hs
		183335 MEFV_HUMAN (84-612): 2.1e-90: 298: 15.61		NLRP1_HUMAN (2-186): 1.66e-17: 90.5: 18.42
+	Hs
		1162057 TRI65_HUMAN (106-574): 6.26e-76: 253: 19.11		NLRP1_HUMAN (2-186): 1.66e-17: 90.5: 18.42
+	Hs
		1318350 TRIM8_HUMAN (6-382): 1.18e-71: 243: 22.05		NOD2_HUMAN (796-1032): 2.65e-20: 99.4: 25.32
+	Hs
		1162063 TRI65_HUMAN (106-574): 6.26e-76: 253: 19.11		NLRC4_HUMAN (582-844): 1.45e-09: 64.3: 13.59
+	Hs
		1223391 TRI22_HUMAN (1-141): 4.74e-20: 95.9: 22.92		NOD2_HUMAN (796-1032): 2.65e-20: 99.4: 25.32
+	Hs
		1149907 TRI68_HUMAN (5-292): 8.23e-20: 95.1: 15.49		NLRP1_HUMAN (2-186): 1.66e-17: 90.5: 18.42
+	Hs
		135016 TRI38_HUMAN (5-258): 1.54e-17: 87.8: 13.23		NLRP6_HUMAN (772-1030): 3.44e-18: 92.5: 25.28
+	Hs
		702498 TRI22_HUMAN (1-141): 4.74e-20: 95.9: 22.92		C2TA_HUMAN (771-1028): 6.92e-13: 75.1: 16.19