HitPredict

Interactor 1: FBXL3 (Q8C4V4)
F-box/LRR-repeat protein 3 (F-box and leucine-rich repeat protein 3A) (F-box/LRR-repeat protein 3A) (Protein after-hours) (Protein overtime)
Gene: FBXL3

Interactor 2: SKP1 (Q9WTX5)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (S-phase kinase-associated protein 1A) (p19A) (p19skp1)
Gene: SKP1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	23503662, 23452855
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	F-box-like~Skp1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 428 Mm			1 163
+	Hs
		929115 FBXL3_HUMAN (1-428): 0: 818: 97.20		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39
+	Mm
		1206354 FXL21_MOUSE (19-428): 0: 724: 75.18		SKP1_MOUSE (1-163): 3.56e-91: 263: 100.00
+	Hs
		929114 FXL21_HUMAN (16-428): 0: 718: 72.73		SKP1_HUMAN (1-163): 5.9e-91: 263: 99.39