Interactor 1: APBB1 (O00213)
Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65)
Gene: APBB1
Interactor 2: A4 (P05067)
Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
Gene: APP
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.98 | 1.00 | 0.993 |
The method score is based on:
Property | Details |
---|---|
Experiments | 12153398, 19334058, 17428983, 8887653, 9837937, 16049941, 23531501, 35914814, 17368826, 15331662, 15044485, 20205790, 18096514, 28514442, 9045663, 8855266, 10081969, 33961781, 25397632, 16223726 and 8 others
more... |
Identification Methods | pull down, affinity chromatography technology, two hybrid, protein complementation assay, anti tag coimmunoprecipitation, validated two hybrid, nuclear magnetic resonance, two hybrid fragment pooling approach, two hybrid array, two hybrid pooling approach and 1 others
more... |
Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | APP_amyloid~PID |
Common GO terms | GO:0005737 - cytoplasm GO:0005783 - endoplasmic reticulum GO:0005886 - plasma membrane GO:0007409 - axonogenesis GO:0030426 - growth cone and 2 others more... |
Homologous interactions | 14 |
Homologous interactions
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024