HitPredict

Interactor 1: RYBP (Q8CCI5)
RING1 and YY1-binding protein (Death effector domain-associated factor) (DED-associated factor)
Gene: RYBP

Interactor 2: PCGF6 (Q99NA9)
Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134)
Gene: PCGF6

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	22325148
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RAWUL~YAF2_RYBP
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0006338 - chromatin remodeling GO:0031519 - PcG protein complex GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 228 Mm			1 353
+	Hs
		1233190 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		PCGF6_HUMAN (45-353): 1.29e-79: 249: 93.55
+	Hs
		718013 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		BMI1_HUMAN (120-352): 9.29e-64: 207: 34.71
+	Hs
		718410 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		PCGF2_HUMAN (120-353): 1.69e-60: 199: 33.47
+	Mm
		620789 RYBP_MOUSE (1-228): 4.83e-60: 190: 100.00		PCGF2_MOUSE (120-353): 2.16e-57: 191: 34.29
+	Hs
		1108517 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		PCGF3_HUMAN (123-344): 1.33e-57: 188: 34.86
+	Hs
		718000 YAF2_HUMAN (3-227): 1.42e-52: 169: 53.33		BMI1_HUMAN (120-352): 9.29e-64: 207: 34.71
+	Mm
		1208119 RYBP_MOUSE (1-228): 4.83e-60: 190: 100.00		PCGF1_MOUSE (120-350): 4.42e-55: 182: 35.90
+	Hs
		1233178 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		PCGF1_HUMAN (120-350): 1.98e-55: 183: 35.90
+	Hs
		718409 YAF2_HUMAN (3-227): 1.42e-52: 169: 53.33		PCGF2_HUMAN (120-353): 1.69e-60: 199: 33.47
+	Hs
		1108516 YAF2_HUMAN (3-227): 1.42e-52: 169: 53.33		PCGF3_HUMAN (123-344): 1.33e-57: 188: 34.86
+	Hs
		1197570 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		PCGF5_HUMAN (120-347): 7.74e-46: 158: 31.98
+	Mm
		1208123 RYBP_MOUSE (1-228): 4.83e-60: 190: 100.00		RING2_MOUSE (106-306): 2.34e-36: 136: 16.67
+	Hs
		1233162 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		RING2_HUMAN (106-306): 2.95e-36: 135: 16.67
+	Mm
		1307837 YAF2_MOUSE (3-227): 4.01e-57: 181: 54.67		RING2_MOUSE (106-306): 2.34e-36: 136: 16.67
+	Hs
		585013 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		RO52_HUMAN (123-312): 2.23e-30: 122: 17.80
+	Hs
		282696 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		RNF8_HUMAN (46-220): 3.9e-29: 118: 23.73
+	Hs
		1019331 YAF2_HUMAN (3-227): 1.42e-52: 169: 53.33		TRI26_HUMAN (123-320): 2.68e-34: 134: 19.61
+	Mm
		193411 RYBP_MOUSE (1-228): 4.83e-60: 190: 100.00		RING1_MOUSE (106-234): 4.47e-27: 112: 21.54
+	Hs
		987991 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		RING1_HUMAN (106-234): 9.51e-27: 111: 21.54
+	Hs
		987989 YAF2_HUMAN (3-227): 1.42e-52: 169: 53.33		RING1_HUMAN (106-234): 9.51e-27: 111: 21.54