HitPredict

Interactor 1: RYBP (Q8CCI5)
RING1 and YY1-binding protein (Death effector domain-associated factor) (DED-associated factor)
Gene: RYBP

Interactor 2: RING2 (Q9CQJ4)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING-type E3 ubiquitin transferase RING2)
Gene: Rnf2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.958

Property	Details
Experiments	28111200, 17070805, 22325148, 20471950, 22496869, 23395003, 10369680
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RAWUL~YAF2_RYBP
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0031519 - PcG protein complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 228 Mm			1 336
+	Hs
		1233162 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		RING2_HUMAN (1-336): 2.74e-106: 315: 99.70
+	Mm
		1307837 YAF2_MOUSE (3-227): 4.01e-57: 181: 54.67		RING2_MOUSE (1-336): 2.13e-106: 316: 100.00
+	Mm
		193411 RYBP_MOUSE (1-228): 4.83e-60: 190: 100.00		RING1_MOUSE (10-336): 8.61e-69: 222: 52.00
+	Hs
		987991 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		RING1_HUMAN (10-336): 3.44e-66: 215: 51.75
+	Hs
		987989 YAF2_HUMAN (3-227): 1.42e-52: 169: 53.33		RING1_HUMAN (10-336): 3.44e-66: 215: 51.75
+	Hs
		1233190 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		PCGF6_HUMAN (30-293): 1.72e-44: 157: 15.36
+	Mm
		1208122 RYBP_MOUSE (1-228): 4.83e-60: 190: 100.00		PCGF6_MOUSE (31-293): 9.54e-43: 152: 16.17
+	Hs
		1108517 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		PCGF3_HUMAN (36-334): 2.56e-43: 151: 17.16
+	Hs
		718013 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		BMI1_HUMAN (34-332): 2.52e-42: 151: 16.83
+	Hs
		718410 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		PCGF2_HUMAN (34-332): 3.57e-40: 145: 15.51
+	Hs
		1197570 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		PCGF5_HUMAN (34-334): 2.53e-39: 141: 18.24
+	Mm
		620789 RYBP_MOUSE (1-228): 4.83e-60: 190: 100.00		PCGF2_MOUSE (34-332): 1.26e-37: 139: 16.17
+	Hs
		585013 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		RO52_HUMAN (36-249): 1.63e-36: 139: 13.08
+	Hs
		1108516 YAF2_HUMAN (3-227): 1.42e-52: 169: 53.33		PCGF3_HUMAN (36-334): 2.56e-43: 151: 17.16
+	Hs
		1233178 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		PCGF1_HUMAN (28-336): 1.37e-35: 131: 16.56
+	Hs
		718000 YAF2_HUMAN (3-227): 1.42e-52: 169: 53.33		BMI1_HUMAN (34-332): 2.52e-42: 151: 16.83
+	Mm
		1208119 RYBP_MOUSE (1-228): 4.83e-60: 190: 100.00		PCGF1_MOUSE (28-336): 1.86e-34: 128: 16.24
+	Hs
		536924 RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12		TRI27_HUMAN (36-244): 3.8e-32: 127: 14.22
+	Hs
		718409 YAF2_HUMAN (3-227): 1.42e-52: 169: 53.33		PCGF2_HUMAN (34-332): 3.57e-40: 145: 15.51
+	Hs
		1019331 YAF2_HUMAN (3-227): 1.42e-52: 169: 53.33		TRI26_HUMAN (36-283): 2.67e-35: 136: 17.05