HitPredict

Interactor 1: APC2 (Q8H1U5)
Anaphase-promoting complex subunit 2 (Cyclosome subunit 2)
Gene: APC2

Interactor 2: APC11 (Q9M9L0)
Anaphase-promoting complex subunit 11 (Cyclosome subunit 11)
Gene: APC11

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.831

Property	Details
Experiments	14508008, 20706207
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	ANAPC2~zf-ANAPC11, Cullin~zf-ANAPC11
Common GO terms	GO:0005634 - nucleus GO:0005680 - anaphase-promoting complex GO:0006511 - ubiquitin-dependent protein catabolic process GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 865 At			1 84
+	Hs
		1348495 ANC2_HUMAN (49-865): 0: 674: 30.43		APC11_HUMAN (1-84): 2.24e-28: 99: 71.43
+	Dm
		1180483 Q9W1E5_DROME (76-865): 0: 641: 29.43		Q7KA43_DROME (1-82): 7.52e-28: 97.8: 60.98
+	At
		1275960 CUL1_ARATH (123-854): 0: 628: 15.32		RBX1A_ARATH (2-84): 8.37e-28: 98.6: 36.36
+	At
		1275966 CUL3A_ARATH (150-854): 1.21e-138: 431: 14.15		RBX1A_ARATH (2-84): 8.37e-28: 98.6: 36.36
+	Hs
		921251 CUL1_HUMAN (181-857): 3.33e-137: 428: 14.01		RBX1_HUMAN (2-84): 1.76e-28: 100: 36.36
+	Mm
		921509 CUL1_MOUSE (181-857): 3.06e-137: 428: 14.01		RBX1_MOUSE (2-84): 1.76e-28: 100: 36.36
+	Dm
		1097212 CUL1_DROME (181-857): 4.93e-137: 428: 14.05		RBX1A_DROME (2-84): 3.24e-28: 99.4: 36.36
+	Dm
		1097197 CUL1_DROME (181-857): 4.93e-137: 428: 14.05		RBX1B_DROME (2-84): 7.9e-26: 93.6: 34.48
+	Mm
		921499 CUL4A_MOUSE (450-853): 1.01e-134: 421: 17.61		RBX1_MOUSE (2-84): 1.76e-28: 100: 36.36
+	At
		1275962 CUL3B_ARATH (147-854): 2.03e-135: 422: 14.00		RBX1A_ARATH (2-84): 8.37e-28: 98.6: 36.36
+	Hs
		921255 CUL4B_HUMAN (383-853): 2.64e-131: 417: 15.51		RBX1_HUMAN (2-84): 1.76e-28: 100: 36.36
+	Hs
		1041242 CUL1_HUMAN (181-857): 3.33e-137: 428: 14.01		RBX2_HUMAN (3-84): 1.55e-22: 85.1: 35.71
+	Hs
		921253 CUL3_HUMAN (115-854): 2.34e-131: 413: 14.39		RBX1_HUMAN (2-84): 1.76e-28: 100: 36.36
+	Dm
		1213855 Q8IP45_DROME (160-854): 1.3e-129: 413: 13.28		RBX1A_DROME (2-84): 3.24e-28: 99.4: 36.36
+	Hs
		921254 CUL4A_HUMAN (175-853): 7.03e-131: 411: 15.16		RBX1_HUMAN (2-84): 1.76e-28: 100: 36.36
+	Dm
		1213836 Q8IP45_DROME (160-854): 1.3e-129: 413: 13.28		RBX1B_DROME (2-84): 7.9e-26: 93.6: 34.48
+	Mm
		1111822 CUL4A_MOUSE (450-853): 1.01e-134: 421: 17.61		RBX2_MOUSE (3-84): 1.68e-22: 85.1: 35.71
+	Hs
		1043627 CUL4B_HUMAN (383-853): 2.64e-131: 417: 15.51		RBX2_HUMAN (3-84): 1.55e-22: 85.1: 35.71
+	Hs
		1042735 CUL3_HUMAN (115-854): 2.34e-131: 413: 14.39		RBX2_HUMAN (3-84): 1.55e-22: 85.1: 35.71
+	Hs
		296909 CUL3_HUMAN (115-854): 2.34e-131: 413: 14.39		LTN1_HUMAN (10-80): 1.07e-18: 80.5: 26.32