HitPredict

Interactor 1: Q8IMX8 (Q8IMX8)
U6 snRNA-associated Sm-like protein LSm3
Gene: LSm3

Interactor 2: Q9W087 (Q9W087)
U6 snRNA-associated Sm-like protein LSm8
Gene: l(3)neo7

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	37061542, 22036573, unassigned1513, unassigned2874
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	LSM~LSM
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005688 - U6 snRNP GO:0046540 - U4/U6 x U5 tri-snRNP complex GO:0071011 - precatalytic spliceosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 103 Dm			1 95
+	Hs
		321387 LSM3_HUMAN (1-103): 4.31e-38: 125: 76.70		LSM8_HUMAN (2-95): 1.25e-33: 113: 69.15
+	Mm
		912214 LSM3_MOUSE (1-103): 4.31e-38: 125: 76.70		LSM8_MOUSE (2-95): 1.25e-33: 113: 69.15
+	Hs
		167680 LSM3_HUMAN (1-103): 4.31e-38: 125: 76.70		LSM1_HUMAN (2-90): 3.41e-25: 93: 26.97
+	Mm
		912216 LSM3_MOUSE (1-103): 4.31e-38: 125: 76.70		LSM1_MOUSE (2-90): 3.52e-25: 93: 26.97
+	Hs
		538892 LSM3_HUMAN (1-103): 4.31e-38: 125: 76.70		RSMB_HUMAN (2-75): 1.3e-23: 91.4: 31.33
+	Hs
		321392 RSMN_HUMAN (24-103): 3.91e-27: 101: 21.43		LSM8_HUMAN (2-95): 1.25e-33: 113: 69.15
+	Hs
		321370 RSMB_HUMAN (24-103): 1.27e-26: 99.7: 21.43		LSM8_HUMAN (2-95): 1.25e-33: 113: 69.15
+	Hs
		912202 LSM3_HUMAN (1-103): 4.31e-38: 125: 76.70		LSM7_HUMAN (4-74): 1.57e-23: 87.6: 29.33
+	Sp
		251585 LSM3_SCHPO (10-99): 5.37e-30: 104: 60.00		LSM8_SCHPO (3-95): 3.32e-30: 104: 41.94
+	Hs
		912020 LSM3_HUMAN (1-103): 4.31e-38: 125: 76.70		RUXG_HUMAN (4-74): 1.42e-21: 81.8: 29.58
+	Hs
		167663 RSMB_HUMAN (24-103): 1.27e-26: 99.7: 21.43		LSM1_HUMAN (2-90): 3.41e-25: 93: 26.97
+	Hs
		538899 RSMN_HUMAN (24-103): 3.91e-27: 101: 21.43		RSMB_HUMAN (2-75): 1.3e-23: 91.4: 31.33
+	Hs
		538826 RSMB_HUMAN (24-103): 1.27e-26: 99.7: 21.43		RSMB_HUMAN (2-75): 1.3e-23: 91.4: 31.33
+	Dm
		984934 SMD2_DROME (1-96): 2.16e-27: 98.5: 30.30		RSMB_DROME (3-69): 1.38e-23: 90.7: 32.88
+	Hs
		539178 RSMB_HUMAN (24-103): 1.27e-26: 99.7: 21.43		LSM7_HUMAN (4-74): 1.57e-23: 87.6: 29.33
+	Hs
		912026 RSMN_HUMAN (24-103): 3.91e-27: 101: 21.43		RUXG_HUMAN (4-74): 1.42e-21: 81.8: 29.58
+	Hs
		538891 RSMB_HUMAN (24-103): 1.27e-26: 99.7: 21.43		RUXG_HUMAN (4-74): 1.42e-21: 81.8: 29.58
+	Hs
		68412 RSMN_HUMAN (24-103): 3.91e-27: 101: 21.43		RUXGL_HUMAN (4-74): 1.04e-19: 77.2: 29.58
+	Hs
		68400 RSMB_HUMAN (24-103): 1.27e-26: 99.7: 21.43		RUXGL_HUMAN (4-74): 1.04e-19: 77.2: 29.58