HitPredict

Interactor 1: LUBEL (Q8IPJ3)
E3 ubiquitin-protein ligase lubel (EC 2.3.2.31) (Linear Ubiquitin E3 ligase)
Gene: LUBEL

Interactor 2: CRK (Q9XYM0)
Adapter molecule Crk
Gene: CRK

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.439

Property	Details
Experiments	37061542
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 2892 Dm			1 271
+	Dm
		1214028 LUBEL_DROME (1-2892): 0: 1205: 100.00		Q95RW2_DROME (1-271): 2.09e-63: 201: 93.36
+	Hs
		855831 ARI1_HUMAN (2419-2885): 2.33e-133: 433: 18.33		VAV2_HUMAN (9-257): 4.51e-32: 126: 16.34
+	Hs
		412301 RNF31_HUMAN (2256-2889): 1.39e-124: 424: 28.04		FYN_HUMAN (112-239): 9.59e-14: 72.8: 21.21
+	Dm
		69318 A9UN74_DROME (1-174): 9.14e-83: 273: 99.43		CRK_DROME (1-271): 1.3e-71: 222: 100.00
+	Hs
		226784 PRKN_HUMAN (2376-2726): 1.96e-67: 238: 15.59		CRKL_HUMAN (4-267): 5.07e-52: 173: 42.72
+	Hs
		523051 CUL9_HUMAN (2385-2869): 4.96e-89: 328: 15.74		SRC_HUMAN (157-265): 2.41e-10: 62.4: 10.62
+	Hs
		226448 PRKN_HUMAN (2376-2726): 1.96e-67: 238: 15.59		PLCG2_HUMAN (1-270): 6.04e-38: 143: 13.48
+	Hs
		226483 PRKN_HUMAN (2376-2726): 1.96e-67: 238: 15.59		PLCG1_HUMAN (2-269): 1.17e-37: 142: 16.51
+	Hs
		227109 PRKN_HUMAN (2376-2726): 1.96e-67: 238: 15.59		GRB2_HUMAN (204-256): 1.59e-12: 67: 27.78
+	Hs
		226294 PRKN_HUMAN (2376-2726): 1.96e-67: 238: 15.59		YES_HUMAN (179-265): 8.33e-11: 63.9: 15.73
+	Hs
		229185 PRKN_HUMAN (2376-2726): 1.96e-67: 238: 15.59		CD2AP_HUMAN (97-198): 3.03e-10: 62.1: 17.14
+	Hs
		924484 ANK2_HUMAN (1474-2528): 2.32e-16: 89: 13.24		GRB2_HUMAN (204-256): 1.59e-12: 67: 27.78