Interactor 1: TR10A (O00220)
Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)
Gene: TNFRSF10A

Interactor 2: TR10B (O14763)
Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)
Gene: TNFRSF10B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.927

The method score is based on:

Property Details
Experiments 28514442, 29795330, 33961781, 15388581, 19427028
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Death~Death, TNFR_c6~TNFR_c6
Common GO terms GO:0005886 - plasma membrane
GO:0006915 - apoptotic process
GO:0007250 - activation of NF-kappaB-inducing kinase activity
GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors
GO:0009986 - cell surface
and 5 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 468
Hs

1 440
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024