HitPredict

Interactor 1: NCK (Q8IPW2)
SH2/SH3 adapter protein dreadlocks
Gene: dock

Interactor 2: PAK (Q9VI13)
Serine/threonine-protein kinase Pak (EC 2.7.11.1)
Gene: PAK

Species: Drosophila melanogaster

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.591

Property	Details
Experiments	10399914, 14527437
Identification Methods	anti bait coimmunoprecipitation, two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007411 - axon guidance GO:0030426 - growth cone
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 548 Dm			1 704
+	Hs
		298951 SRBS2_HUMAN (64-383): 7.65e-34: 139: 18.64		AKT2_HUMAN (360-704): 3.07e-132: 400: 22.65
+	Hs
		1054045 GRB14_HUMAN (52-544): 1.27e-37: 147: 12.71		STK26_HUMAN (422-699): 1.9e-121: 370: 41.07
+	Hs
		235609 VINEX_HUMAN (61-447): 9.3e-19: 91.8: 17.29		PAK5_HUMAN (75-698): 1.23e-131: 407: 29.19
+	Hs
		235479 VINEX_HUMAN (61-447): 9.3e-19: 91.8: 17.29		AKT2_HUMAN (360-704): 3.07e-132: 400: 22.65
+	Dm
		112579 M9ND00_DROME (36-318): 8.12e-23: 105: 14.33		HIPPO_DROME (388-704): 4.65e-122: 380: 36.73
+	Hs
		1026152 GRB10_HUMAN (2-544): 1.16e-40: 157: 13.61		PAK1_HUMAN (5-257): 1.14e-38: 152: 30.68
+	Hs
		298975 SRBS2_HUMAN (64-383): 7.65e-34: 139: 18.64		PAK2_HUMAN (5-237): 5.74e-36: 144: 31.65
+	Ce
		1089181 Q95PW9_CAEEL (140-369): 6.81e-20: 93.8: 17.70		PK1_CAEEL (2-228): 1.52e-44: 170: 31.08
+	Mm
		292046 NCK1_MOUSE (88-377): 6.26e-24: 105: 14.33		PAK1_MOUSE (5-257): 1.19e-38: 152: 30.68
+	Hs
		557676 NCK1_HUMAN (88-379): 9.12e-24: 104: 14.24		PAK1_HUMAN (5-257): 1.14e-38: 152: 30.68
+	Hs
		557677 NCK1_HUMAN (88-379): 9.12e-24: 104: 14.24		PAK2_HUMAN (5-237): 5.74e-36: 144: 31.65
+	Hs
		209044 NCK2_HUMAN (86-322): 3.49e-20: 94.6: 15.71		PAK1_HUMAN (5-257): 1.14e-38: 152: 30.68
+	Hs
		277595 NCK1_HUMAN (88-379): 9.12e-24: 104: 14.24		PAK3_HUMAN (5-238): 4.93e-34: 139: 28.57
+	Hs
		277606 ITSN1_HUMAN (7-453): 3.14e-22: 103: 12.64		PAK3_HUMAN (5-238): 4.93e-34: 139: 28.57
+	Hs
		209045 NCK2_HUMAN (86-322): 3.49e-20: 94.6: 15.71		PAK2_HUMAN (5-237): 5.74e-36: 144: 31.65
+	Hs
		235500 VINEX_HUMAN (61-447): 9.3e-19: 91.8: 17.29		PAK2_HUMAN (5-237): 5.74e-36: 144: 31.65
+	Hs
		924536 GRB2_HUMAN (147-210): 4.21e-16: 79.4: 26.56		PAK1_HUMAN (5-257): 1.14e-38: 152: 30.68
+	Hs
		1026202 SH3K1_HUMAN (127-340): 2.57e-14: 77.9: 13.43		PAK1_HUMAN (5-257): 1.14e-38: 152: 30.68
+	Hs
		411702 LCK_HUMAN (103-372): 2.54e-15: 80.7: 12.59		PAK2_HUMAN (5-237): 5.74e-36: 144: 31.65
+	Hs
		924538 GRB2_HUMAN (147-210): 4.21e-16: 79.4: 26.56		PAK2_HUMAN (5-237): 5.74e-36: 144: 31.65