Interactor 1: TR10A (O00220)
Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)
Gene: TNFRSF10A
Interactor 2: TNF10 (P50591)
Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253)
Gene: TNFSF10
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.82 | 1.00 | 0.908 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 9082980, 10894161, 19427028, 10894160, 20103630 |
| Identification Methods | affinity chromatography technology, anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation, surface plasmon resonance |
| Interaction Type | physical association, association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | TNF~TNFR_c6 |
| Common GO terms | GO:0005886 - plasma membrane GO:0006915 - apoptotic process GO:0007165 - signal transduction GO:0043065 - positive regulation of apoptotic process GO:0045569 - TRAIL binding |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
