Interactor 1: TR10A (O00220)
Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)
Gene: TNFRSF10A
Interactor 2: CASP8 (Q14790)
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Gene: CASP8
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 0.60 | 0.763 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 27321185, 28514442, 29795330, 29274253, 9325248, 33961781, 19343040, 15280356, 15388581, 19427028, 23142077, 10894161, 17047155, 17898872, 22421964, 21785459, 20103630 |
| Identification Methods | affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors GO:0036462 - TRAIL-activated apoptotic signaling pathway GO:0043065 - positive regulation of apoptotic process and 2 others more... |
| Homologous interactions | 16 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
