HitPredict

Interactor 1: IKBE (O00221)
NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon)
Gene: NFKBIE

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35256949, 29128334
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 500 Hs			1 465
+	Mm
		222606 IKBE_MOUSE (140-500): 7.25e-73: 237: 80.82		PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66
+	Hs
		227310 ANK3_HUMAN (1-346): 2.28e-58: 211: 14.37		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		229176 ASB3_HUMAN (199-468): 5.42e-32: 130: 16.55		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226494 NFKB1_HUMAN (386-481): 8.64e-13: 72.8: 24.51		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		227985 ANKH1_HUMAN (15-285): 6.48e-09: 61: 10.87		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		227186 NFKB2_HUMAN (420-500): 5.33e-09: 60.9: 23.00		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		476011 MIB1_HUMAN (166-500): 1.3e-69: 241: 23.85		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		312683 ASB3_HUMAN (199-468): 5.42e-32: 130: 16.55		ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82
+	Xl
		1151527 MIB1_XENLA (272-500): 1.66e-39: 154: 21.74		Q7SY79_XENLA (1-149): 2.25e-49: 179: 19.33
+	Mm
		1141375 IKBB_MOUSE (226-441): 4.25e-26: 110: 37.21		ARI2_MOUSE (222-464): 1.03e-64: 218: 20.82
+	Hs
		475034 IKBB_HUMAN (254-447): 4.47e-26: 110: 37.50		UBB_HUMAN (1-234): 1.14e-59: 197: 17.92
+	Dr
		47643 A0AR23_DANRE (257-481): 5.85e-14: 76.6: 31.44		F1QHN6_DANRE (1-229): 5.17e-61: 209: 18.30
+	Hs
		474996 NFKB2_HUMAN (420-500): 5.33e-09: 60.9: 23.00		UBB_HUMAN (1-234): 1.14e-59: 197: 17.92
+	Dr
		47652 A0AR23_DANRE (257-481): 5.85e-14: 76.6: 31.44		Q6IS68_DANRE (1-154): 1.67e-49: 180: 19.36
+	Hs
		476634 ASB3_HUMAN (199-468): 5.42e-32: 130: 16.55		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		476162 MIB2_HUMAN (84-446): 1.56e-24: 109: 20.81		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		475511 DAPK1_HUMAN (4-284): 1.05e-20: 97.9: 10.68		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		475361 IKBA_HUMAN (252-330): 1.11e-12: 70.9: 30.00		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		476024 ANKH1_HUMAN (15-285): 6.48e-09: 61: 10.87		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		475636 NFKB2_HUMAN (420-500): 5.33e-09: 60.9: 23.00		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47