HitPredict

Interactor 1: IKBE (O00221)
NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon)
Gene: NFKBIE

Interactor 2: RELB (Q01201)
Transcription factor RelB (I-Rel)
Gene: RELB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	28514442, 27609421, 33961781, 14743216
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~RHD_dimer
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 500 Hs			1 579
+	Mm
		222602 IKBE_MOUSE (140-500): 7.25e-73: 237: 80.82		RELB_MOUSE (18-579): 0: 690: 88.30
+	Hs
		964488 IKBB_HUMAN (254-447): 4.47e-26: 110: 37.50		RELB_HUMAN (1-579): 0: 787: 100.00
+	Mm
		981549 NFKB2_MOUSE (343-498): 9.78e-22: 100: 23.39		RELB_MOUSE (18-579): 0: 690: 88.30
+	Rn
		1144369 IKBA_RAT (200-496): 3.73e-78: 248: 31.79		Q7TQN4_RAT (111-544): 7.96e-156: 459: 41.63
+	Mm
		222601 IKBE_MOUSE (140-500): 7.25e-73: 237: 80.82		TF65_MOUSE (111-544): 1.05e-156: 461: 41.63
+	Hs
		587410 BCL3_HUMAN (145-486): 2.53e-73: 240: 32.49		NFKB1_HUMAN (87-419): 2.35e-140: 432: 37.70
+	Hs
		595669 BCL3_HUMAN (145-486): 2.53e-73: 240: 32.49		NFKB2_HUMAN (107-511): 7.99e-123: 385: 33.10
+	Dm
		957297 CACT_DROME (179-494): 5.91e-69: 230: 25.66		DIF_DROME (90-487): 1.44e-126: 388: 32.52
+	Dm
		547613 CACT_DROME (179-494): 5.91e-69: 230: 25.66		DORS_DROME (122-458): 3.9e-110: 354: 39.60
+	Mm
		546808 IKBB_MOUSE (226-441): 4.25e-26: 110: 37.21		REL_MOUSE (120-551): 1.82e-158: 467: 38.31
+	Hs
		981586 IKBB_HUMAN (254-447): 4.47e-26: 110: 37.50		REL_HUMAN (120-551): 2.71e-156: 463: 36.19
+	Mm
		978962 IKBB_MOUSE (226-441): 4.25e-26: 110: 37.21		TF65_MOUSE (111-544): 1.05e-156: 461: 41.63
+	Dm
		974284 CACT_DROME (179-494): 5.91e-69: 230: 25.66		NFKB1_DROME (83-414): 2.1e-103: 335: 30.35
+	Mm
		978989 NFKB2_MOUSE (343-498): 9.78e-22: 100: 23.39		TF65_MOUSE (111-544): 1.05e-156: 461: 41.63
+	Hs
		978766 IKBB_HUMAN (254-447): 4.47e-26: 110: 37.50		TF65_HUMAN (111-527): 2.75e-151: 447: 42.08
+	Hs
		587589 IKBB_HUMAN (254-447): 4.47e-26: 110: 37.50		NFKB1_HUMAN (87-419): 2.35e-140: 432: 37.70
+	Mm
		638473 NFKB2_MOUSE (343-498): 9.78e-22: 100: 23.39		NFKB1_MOUSE (87-419): 3.79e-134: 416: 37.70
+	Hs
		587698 IKBZ_HUMAN (258-482): 3.66e-15: 80.1: 30.77		NFKB1_HUMAN (87-419): 2.35e-140: 432: 37.70
+	Hs
		961391 IKBB_HUMAN (254-447): 4.47e-26: 110: 37.50		NFKB2_HUMAN (107-511): 7.99e-123: 385: 33.10
+	Hs
		166934 ANR28_HUMAN (30-458): 1.63e-51: 190: 15.28		NFAC4_HUMAN (24-510): 5.94e-78: 265: 18.15