Interactor 1: DCP2 (Q8IU60)
m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc)
Gene: DCP2

Interactor 2: DCP1B (Q8IZD4)
mRNA-decapping enzyme 1B (EC 3.6.1.62)
Gene: DCP1B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.950

The method score is based on:

Property Details
Experiments 15231747, 26186194, 28514442, 33961781, 16364915, 24778252
Identification Methods two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains DCP1~DCP2, DCP1~NUDIX
Common GO terms GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000932 - P-body
GO:0005829 - cytosol
GO:0140933 - 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 420
Hs

1 617
+ Hs
+ Dm
+ At

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Last updated: 15 Jul 2024