HitPredict

Interactor 1: IKBE (O00221)
NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon)
Gene: NFKBIE

Interactor 2: ANKH1 (Q8IWZ3)
Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK)
Gene: ANKHD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	21988832, 14743216
Identification Methods	two hybrid, tandem affinity purification, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank_2~Ank_2, Ank_2~Ank_4
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 500 Hs			1 2542
+	Hs
		257652 ANR17_HUMAN (5-353): 2.9e-39: 154: 13.84		ANKH1_HUMAN (1-2542): 0: 1432: 100.00
+	Mm
		103608 ANK2_MOUSE (1-500): 1.59e-84: 287: 17.26		ANK3_MOUSE (1-391): 3.31e-87: 321: 19.95
+	Mm
		103591 ANK3_MOUSE (1-346): 4.34e-56: 204: 15.23		ANK3_MOUSE (1-391): 3.31e-87: 321: 19.95
+	Hs
		166913 ANK2_HUMAN (162-497): 6.94e-75: 259: 19.01		ANR28_HUMAN (1159-1401): 6.69e-59: 225: 28.81
+	Hs
		166882 BCL3_HUMAN (145-486): 2.53e-73: 240: 32.49		ANR28_HUMAN (1159-1401): 6.69e-59: 225: 28.81
+	Hs
		167028 ANR28_HUMAN (30-458): 1.63e-51: 190: 15.28		ANFY1_HUMAN (778-1387): 4.2e-70: 261: 16.69
+	Hs
		166971 ANR28_HUMAN (30-458): 1.63e-51: 190: 15.28		ANR52_HUMAN (5-393): 1.49e-66: 249: 16.83
+	Hs
		166919 ANK3_HUMAN (1-346): 2.28e-58: 211: 14.37		ANR28_HUMAN (1159-1401): 6.69e-59: 225: 28.81
+	Hs
		167036 ANR50_HUMAN (192-500): 5.54e-56: 203: 18.24		ANR28_HUMAN (1159-1401): 6.69e-59: 225: 28.81
+	Hs
		166849 ANR28_HUMAN (30-458): 1.63e-51: 190: 15.28		ANR28_HUMAN (1159-1401): 6.69e-59: 225: 28.81
+	Hs
		167014 TNKS2_HUMAN (162-500): 2.62e-51: 190: 13.43		ANR28_HUMAN (1159-1401): 6.69e-59: 225: 28.81
+	Hs
		1329533 TNKS2_HUMAN (162-500): 2.62e-51: 190: 13.43		TNKS2_HUMAN (1194-1530): 3.72e-45: 182: 23.06
+	Hs
		166869 ANR28_HUMAN (30-458): 1.63e-51: 190: 15.28		TNKS1_HUMAN (1194-1429): 2.78e-41: 170: 27.41
+	Hs
		166969 ANR28_HUMAN (30-458): 1.63e-51: 190: 15.28		ANR44_HUMAN (30-237): 3.12e-32: 140: 12.45