HitPredict

Interactor 1: IKBE (O00221)
NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon)
Gene: NFKBIE

Interactor 2: UACA (Q9BZF9)
Uveal autoantigen with coiled-coil domains and ankyrin repeats
Gene: UACA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Ank_2, Ank_2~Ank_3
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 500 Hs			1 1416
+	Mm
		103608 ANK2_MOUSE (1-500): 1.59e-84: 287: 17.26		ANK3_MOUSE (5-387): 4.53e-65: 246: 13.59
+	Hs
		166913 ANK2_HUMAN (162-497): 6.94e-75: 259: 19.01		ANR28_HUMAN (72-344): 7.07e-54: 208: 17.58
+	Mm
		103591 ANK3_MOUSE (1-346): 4.34e-56: 204: 15.23		ANK3_MOUSE (5-387): 4.53e-65: 246: 13.59
+	Hs
		166882 BCL3_HUMAN (145-486): 2.53e-73: 240: 32.49		ANR28_HUMAN (72-344): 7.07e-54: 208: 17.58
+	Mm
		1193395 MIB1_MOUSE (166-500): 1.53e-69: 241: 23.85		MIB1_MOUSE (7-577): 1.51e-52: 203: 12.70
+	Hs
		1205972 MIB1_HUMAN (166-500): 1.3e-69: 241: 23.85		MIB1_HUMAN (7-577): 1.39e-52: 203: 12.70
+	Hs
		166919 ANK3_HUMAN (1-346): 2.28e-58: 211: 14.37		ANR28_HUMAN (72-344): 7.07e-54: 208: 17.58
+	Hs
		167036 ANR50_HUMAN (192-500): 5.54e-56: 203: 18.24		ANR28_HUMAN (72-344): 7.07e-54: 208: 17.58
+	Hs
		883487 ANK2_HUMAN (162-497): 6.94e-75: 259: 19.01		RIPK4_HUMAN (93-382): 1.35e-34: 145: 20.62
+	Hs
		166849 ANR28_HUMAN (30-458): 1.63e-51: 190: 15.28		ANR28_HUMAN (72-344): 7.07e-54: 208: 17.58
+	Hs
		167014 TNKS2_HUMAN (162-500): 2.62e-51: 190: 13.43		ANR28_HUMAN (72-344): 7.07e-54: 208: 17.58
+	Hs
		883555 MIB1_HUMAN (166-500): 1.3e-69: 241: 23.85		RIPK4_HUMAN (93-382): 1.35e-34: 145: 20.62
+	Hs
		883496 ANK3_HUMAN (1-346): 2.28e-58: 211: 14.37		RIPK4_HUMAN (93-382): 1.35e-34: 145: 20.62
+	Hs
		1349604 ANR50_HUMAN (192-500): 5.54e-56: 203: 18.24		RAI14_HUMAN (987-1410): 1.86e-29: 129: 32.55
+	Hs
		862028 ANK2_HUMAN (162-497): 6.94e-75: 259: 19.01		DAPK1_HUMAN (160-397): 1.88e-10: 67.9: 11.67
+	Hs
		862070 MIB1_HUMAN (166-500): 1.3e-69: 241: 23.85		DAPK1_HUMAN (160-397): 1.88e-10: 67.9: 11.67
+	Mm
		1193396 MIB1_MOUSE (166-500): 1.53e-69: 241: 23.85		DAPK1_MOUSE (160-397): 2.97e-10: 67.2: 11.67
+	Hs
		1329533 TNKS2_HUMAN (162-500): 2.62e-51: 190: 13.43		TNKS2_HUMAN (49-230): 5.5e-09: 63.2: 28.57
+	Hs
		166869 ANR28_HUMAN (30-458): 1.63e-51: 190: 15.28		TNKS1_HUMAN (11-174): 9.77e-09: 62.4: 27.88