HitPredict

Interactor 1: RN135 (Q8IUD6)
E3 ubiquitin-protein ligase RNF135 (EC 2.3.2.27) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (RING finger protein leading to RIG-I activation) (Riplet) (RING-type E3 ubiquitin transferase RNF135)
Gene: RNF135

Interactor 2: RN135 (Q8IUD6)
E3 ubiquitin-protein ligase RNF135 (EC 2.3.2.27) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (RING finger protein leading to RIG-I activation) (Riplet) (RING-type E3 ubiquitin transferase RNF135)
Gene: RNF135

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.924

The method score is based on:

Property Details
Experiments 25416956, 31006531, 32296183, 35913217, unassigned1304
Identification Methods two hybrid, pull down, affinity chromatography technology, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains SPRY~SPRY, zf-C3HC4_4~zf-C3HC4_4
Common GO terms GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0010494 - cytoplasmic stress granule
and 14 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 432
Hs

1 432
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Last updated: 15 Jul 2024