HitPredict

Interactor 1: RN135 (Q8IUD6)
E3 ubiquitin-protein ligase RNF135 (EC 2.3.2.27) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (RING finger protein leading to RIG-I activation) (Riplet) (RING-type E3 ubiquitin transferase RNF135)
Gene: RNF135

Interactor 2: DHX58 (Q96C10)
ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR)
Gene: DHX58

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	33373584
Identification Methods	x-ray crystallography
Interaction Type	association

Property	Details
Interacting Pfam domains	Helicase_C~SPRY
Common GO terms	GO:0005737 - cytoplasm GO:0045088 - regulation of innate immune response GO:0140374 - antiviral innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 432 Hs			1 678
+	Hs
		1216180 RN135_HUMAN (1-432): 1.44e-108: 328: 100.00		IFIH1_HUMAN (1-674): 7.37e-119: 381: 40.39
+	Hs
		1317601 TRIM7_HUMAN (16-429): 1.25e-96: 301: 18.05		IFIH1_HUMAN (1-674): 7.37e-119: 381: 40.39
+	Hs
		321915 RN135_HUMAN (1-432): 1.44e-108: 328: 100.00		RIGI_HUMAN (1-666): 1.75e-101: 333: 29.89
+	Mm
		1163172 TRI11_MOUSE (6-430): 1.09e-105: 322: 18.97		RIGI_MOUSE (1-666): 3.84e-103: 337: 28.88
+	Hs
		321932 TRIM6_HUMAN (6-426): 2.91e-100: 309: 17.90		RIGI_HUMAN (1-666): 1.75e-101: 333: 29.89
+	Hs
		321931 TRIM7_HUMAN (16-429): 1.25e-96: 301: 18.05		RIGI_HUMAN (1-666): 1.75e-101: 333: 29.89
+	Hs
		536834 TRI27_HUMAN (6-430): 2.77e-107: 328: 16.40		CHD4_HUMAN (2-626): 2.02e-73: 260: 12.48
+	Hs
		1052729 TRI25_HUMAN (15-131): 1.21e-29: 123: 28.21		DHX58_HUMAN (1-678): 6.28e-152: 457: 100.00
+	Hs
		536917 TRI27_HUMAN (6-430): 2.77e-107: 328: 16.40		FANCM_HUMAN (4-542): 6.34e-65: 235: 17.68
+	Hs
		134128 TRI58_HUMAN (6-432): 6.38e-112: 339: 17.48		DDX3X_HUMAN (146-516): 5.67e-56: 203: 16.67
+	Hs
		1052762 TRI25_HUMAN (15-131): 1.21e-29: 123: 28.21		IFIH1_HUMAN (1-674): 7.37e-119: 381: 40.39
+	Mm
		1142634 TRI25_MOUSE (15-135): 1.29e-32: 132: 31.41		RIGI_MOUSE (1-666): 3.84e-103: 337: 28.88
+	Hs
		321897 TRI25_HUMAN (15-131): 1.21e-29: 123: 28.21		RIGI_HUMAN (1-666): 1.75e-101: 333: 29.89
+	Hs
		536749 TRI27_HUMAN (6-430): 2.77e-107: 328: 16.40		IF4A3_HUMAN (2-345): 5e-28: 118: 8.96
+	Hs
		1052806 TRI25_HUMAN (15-131): 1.21e-29: 123: 28.21		DICER_HUMAN (3-515): 7.66e-90: 309: 21.54
+	Hs
		1052656 TRI25_HUMAN (15-131): 1.21e-29: 123: 28.21		CHD4_HUMAN (2-626): 2.02e-73: 260: 12.48
+	Hs
		1261134 TRI41_HUMAN (1-49): 1.37e-09: 62.1: 34.69		DICER_HUMAN (3-515): 7.66e-90: 309: 21.54
+	Hs
		134038 TRI25_HUMAN (15-131): 1.21e-29: 123: 28.21		DDX3X_HUMAN (146-516): 5.67e-56: 203: 16.67
+	Hs
		571451 TRI25_HUMAN (15-131): 1.21e-29: 123: 28.21		DDX5_HUMAN (2-255): 1.99e-37: 150: 15.21
+	Hs
		1052734 TRI25_HUMAN (15-131): 1.21e-29: 123: 28.21		DDX27_HUMAN (2-371): 4.82e-10: 64.9: 16.27