HitPredict

Interactor 1: PSD11 (O00231)
26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5)
Gene: PSMD11

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35509820, 35256949, 23503661
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 422 Hs			1 465
+	Hs
		227037 CSN2_HUMAN (8-419): 1.5e-88: 277: 22.80		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		227483 PSMD6_HUMAN (31-422): 3.57e-77: 246: 13.68		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		228529 CSN4_HUMAN (4-422): 5.53e-72: 233: 14.62		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		121897 PSD12_HUMAN (46-422): 1.57e-66: 220: 12.86		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		227323 CSN1_HUMAN (213-421): 8.68e-44: 161: 16.98		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		121666 PSD11_HUMAN (1-422): 1.54e-117: 351: 100.00		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Sc
		477496 RPN6_YEAST (39-421): 4.48e-81: 257: 45.36		UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72
+	At
		1092149 PSD11_ARATH (10-421): 4.55e-96: 295: 51.94		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		475555 CSN2_HUMAN (8-419): 1.5e-88: 277: 22.80		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		475779 PSMD6_HUMAN (31-422): 3.57e-77: 246: 13.68		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		476293 CSN4_HUMAN (4-422): 5.53e-72: 233: 14.62		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		121918 PSD12_HUMAN (46-422): 1.57e-66: 220: 12.86		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		1091885 PSMD6_ARATH (34-422): 8.51e-66: 216: 14.71		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		799469 CSN1_ARATH (70-421): 1.51e-57: 196: 16.13		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17