HitPredict

Interactor 1: SIAH1 (Q8IUQ4)
E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)
Gene: SIAH1

Interactor 2: PHC2 (Q8IXK0)
Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2)
Gene: PHC2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.707

Property	Details
Experiments	20471960, 25416956, 21516116, 21988832
Identification Methods	affinity chromatography technology, pull down, two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0007283 - spermatogenesis GO:0008270 - zinc ion binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 282 Hs			1 858
+	Hs
		1123980 SIAH1_HUMAN (1-282): 7.29e-121: 348: 100.00		Q59GP6_HUMAN (44-858): 5.95e-44: 174: 26.40
+	Hs
		943071 SIAH1_HUMAN (1-282): 7.29e-121: 348: 100.00		PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40
+	Hs
		1138554 SIAH1_HUMAN (1-282): 7.29e-121: 348: 100.00		SMBT2_HUMAN (447-858): 1.02e-32: 138: 15.69
+	Rn
		1265322 SIAH1_RAT (1-282): 2.65e-120: 347: 99.65		PCLO_RAT (1-793): 3.59e-10: 66.1: 8.37
+	Dm
		1370388 Q9W4W4_DROME (9-279): 4.15e-49: 173: 23.68		Q9VLS7_DROME (70-796): 1.34e-09: 64.2: 10.56