HitPredict

Interactor 1: SIAH1 (Q8IUQ4)
E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)
Gene: SIAH1

Interactor 2: CYBP (Q9HB71)
Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein)
Gene: CACYBP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.755

Property	Details
Experiments	29099417, 11389839, 16085652, 22295074, 37038329, 20181957, 12421809, 23208506
Identification Methods	affinity chromatography technology, pull down, two hybrid, x-ray crystallography, enzymatic study
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0030877 - beta-catenin destruction complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 282 Hs			1 228
+	Mm
		896600 SIA1A_MOUSE (1-282): 2.65e-120: 347: 99.65		CYBP_MOUSE (3-228): 3.8e-93: 274: 92.92
+	Hs
		199150 SIAH2_HUMAN (28-282): 1.74e-103: 306: 83.20		CYBP_HUMAN (1-228): 1.73e-97: 285: 100.00
+	Hs
		1331799 RNF41_HUMAN (25-152): 1.42e-32: 123: 17.65		CYBP_HUMAN (1-228): 1.73e-97: 285: 100.00