HitPredict

Interactor 1: ARMC8 (Q8IUR7)
Armadillo repeat-containing protein 8
Gene: ARMC8

Interactor 2: PKP2 (Q99959)
Plakophilin-2
Gene: PKP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.775

Property	Details
Experiments	29911972, 30482882
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Arm~Arm
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 673 Hs			1 881
+	Hs
		1216817 ARMC8_HUMAN (1-673): 3.83e-127: 393: 100.00		PKP4_HUMAN (27-880): 1.06e-141: 452: 22.22
+	Hs
		717200 ARMC8_HUMAN (1-673): 3.83e-127: 393: 100.00		CTNB1_HUMAN (234-851): 2.18e-137: 429: 14.99
+	Hs
		1216869 ARMC8_HUMAN (1-673): 3.83e-127: 393: 100.00		PKP3_HUMAN (29-870): 8.19e-134: 421: 23.03
+	Hs
		1045974 ARMC8_HUMAN (1-673): 3.83e-127: 393: 100.00		PKP1_HUMAN (107-879): 1.85e-125: 397: 22.99
+	Hs
		134924 ARMC8_HUMAN (1-673): 3.83e-127: 393: 100.00		IMA3_HUMAN (284-809): 3.27e-109: 347: 12.10
+	Hs
		238705 ARMC8_HUMAN (1-673): 3.83e-127: 393: 100.00		IMA7_HUMAN (277-860): 1.31e-101: 328: 11.34
+	Mm
		1148451 SPAG6_MOUSE (61-298): 8.17e-13: 73.2: 19.25		PKP4_MOUSE (27-880): 3.88e-145: 461: 22.34
+	Hs
		131338 IMA3_HUMAN (132-580): 2.48e-43: 165: 12.34		IMA4_HUMAN (281-809): 3.16e-106: 339: 12.78
+	Sp
		293203 IMA2_SCHPO (15-220): 1.35e-27: 119: 16.67		IMA2_SCHPO (278-880): 4.16e-106: 340: 11.49
+	Hs
		238650 IMA5_HUMAN (152-547): 6.76e-28: 120: 13.22		IMA7_HUMAN (277-860): 1.31e-101: 328: 11.34
+	Sp
		144255 IMA1_SCHPO (15-220): 9.69e-21: 98.4: 17.14		IMA2_SCHPO (278-880): 4.16e-106: 340: 11.49