HitPredict

Interactor 1: PSD11 (O00231)
26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5)
Gene: PSMD11

Interactor 2: PSA4 (P25789)
Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L)
Gene: PSMA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	28292943, 35271311
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Proteasome~RPN6_N
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 422 Hs			1 261
+	Hs
		108918 PSD11_HUMAN (1-422): 1.54e-117: 351: 100.00		H0YKT8_HUMAN (25-205): 1.07e-132: 374: 100.00
+	Hs
		121719 PSD11_HUMAN (1-422): 1.54e-117: 351: 100.00		PSA6_HUMAN (2-244): 3.23e-92: 273: 31.84
+	Hs
		121683 PSD11_HUMAN (1-422): 1.54e-117: 351: 100.00		PSA1_HUMAN (4-259): 2.5e-91: 272: 28.57
+	Hs
		121635 PSD11_HUMAN (1-422): 1.54e-117: 351: 100.00		PSA7_HUMAN (5-238): 2.84e-91: 271: 33.19
+	Hs
		108945 PSMD6_HUMAN (31-422): 3.57e-77: 246: 13.68		H0YKT8_HUMAN (25-205): 1.07e-132: 374: 100.00
+	Dm
		574022 PSD11_DROME (4-422): 6.96e-107: 323: 67.46		PSA4_DROME (1-242): 9.91e-93: 275: 72.25
+	Dm
		1180708 PSD11_DROME (4-422): 6.96e-107: 323: 67.46		PSA5_DROME (3-241): 6.79e-89: 265: 32.11
+	Hs
		893638 CSN2_HUMAN (8-419): 1.5e-88: 277: 22.80		PSA6_HUMAN (2-244): 3.23e-92: 273: 31.84
+	Hs
		638133 PSMD6_HUMAN (31-422): 3.57e-77: 246: 13.68		PSA4_HUMAN (1-237): 2.4e-98: 289: 100.00
+	Sc
		619400 RPN6_YEAST (39-421): 4.48e-81: 257: 45.36		PSA3_YEAST (2-245): 2.67e-89: 267: 52.03
+	Sc
		771394 RPN6_YEAST (39-421): 4.48e-81: 257: 45.36		PSA4_YEAST (3-240): 1.72e-87: 262: 32.37
+	Hs
		893673 PSMD6_HUMAN (31-422): 3.57e-77: 246: 13.68		PSA6_HUMAN (2-244): 3.23e-92: 273: 31.84
+	Hs
		637422 PSMD6_HUMAN (31-422): 3.57e-77: 246: 13.68		PSA1_HUMAN (4-259): 2.5e-91: 272: 28.57
+	Hs
		156291 PSMD6_HUMAN (31-422): 3.57e-77: 246: 13.68		PSA7_HUMAN (5-238): 2.84e-91: 271: 33.19
+	Dm
		574028 PSMD6_DROME (31-422): 3.38e-72: 233: 13.93		PSA4_DROME (1-242): 9.91e-93: 275: 72.25
+	Hs
		121684 PSD11_HUMAN (1-422): 1.54e-117: 351: 100.00		PSA2_HUMAN (3-214): 6.04e-42: 145: 38.68
+	Dm
		771297 PSD11_DROME (4-422): 6.96e-107: 323: 67.46		PSA2_DROME (2-221): 4.75e-44: 150: 39.64
+	Sp
		1013779 RPN6_SCHPO (13-419): 1.56e-91: 284: 54.90		PSA4_SCHPO (5-251): 2.17e-40: 141: 34.54
+	Sc
		619525 RPN6_YEAST (39-421): 4.48e-81: 257: 45.36		PSA2_YEAST (1-220): 3.05e-39: 138: 38.01
+	Hs
		637690 PSMD6_HUMAN (31-422): 3.57e-77: 246: 13.68		PSA2_HUMAN (3-214): 6.04e-42: 145: 38.68