HitPredict

Interactor 1: EGFL6 (Q8IUX8)
Epidermal growth factor-like protein 6 (EGF-like protein 6) (MAM and EGF domains-containing gene protein)
Gene: EGFL6

Interactor 2: LRP1B (Q9NZR2)
Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT)
Gene: LRP1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EGF~EGF_CA, EGF_CA~EGF_CA, EGF_CA~FXa_inhibition, EGF_CA~Ldl_recept_b
Common GO terms	GO:0005509 - calcium ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 553 Hs			1 4599
+	Hs
		1069983 PTPRK_HUMAN (402-547): 5.93e-46: 175: 27.78		LRP1B_HUMAN (24-4599): 0: 3417: 100.00
+	Hs
		1048400 PTPRK_HUMAN (402-547): 5.93e-46: 175: 27.78		NID2_HUMAN (4360-4522): 5.4e-12: 74.9: 10.66
+	Hs
		235021 CUBN_HUMAN (86-437): 3.81e-43: 167: 16.05		LRP1_HUMAN (5-268): 9.9e-09: 64.5: 14.24
+	Hs
		132252 DLL1_HUMAN (9-308): 3.73e-36: 145: 18.51		NOTC1_HUMAN (12-229): 5.06e-12: 75.3: 14.10
+	Hs
		132255 DLL1_HUMAN (9-308): 3.73e-36: 145: 18.51		NOTC2_HUMAN (11-260): 3.49e-09: 66: 14.40
+	Hs
		624332 TENA_HUMAN (1-219): 6.16e-28: 121: 18.72		NID2_HUMAN (4360-4522): 5.4e-12: 74.9: 10.66
+	Hs
		537515 FBLN2_HUMAN (94-288): 8.19e-30: 126: 27.39		NID1_HUMAN (3473-3718): 1.32e-09: 67.1: 13.83
+	Dm
		422964 NOTCH_DROME (62-417): 1.15e-25: 114: 15.39		Q9W4Y4_DROME (1063-1169): 3.53e-11: 72.4: 35.71
+	Hs
		804372 NOTC3_HUMAN (66-283): 2.24e-24: 110: 21.21		NOTC1_HUMAN (12-229): 5.06e-12: 75.3: 14.10
+	Dm
		422709 NOTCH_DROME (62-417): 1.15e-25: 114: 15.39		NOTCH_DROME (14-189): 1.52e-10: 70.3: 15.74
+	Hs
		980576 NOTC3_HUMAN (66-283): 2.24e-24: 110: 21.21		NOTC2_HUMAN (11-260): 3.49e-09: 66: 14.40
+	Hs
		992726 NOTC3_HUMAN (66-283): 2.24e-24: 110: 21.21		LRP1_HUMAN (5-268): 9.9e-09: 64.5: 14.24
+	Dm
		246971 TENM_DROME (2-195): 1.27e-23: 108: 13.74		Q9VBN0_DROME (4133-4367): 2.7e-09: 66: 15.36
+	Dm
		90684 E1JHA6_DROME (3-176): 1.06e-21: 102: 14.84		NOTCH_DROME (14-189): 1.52e-10: 70.3: 15.74
+	Hs
		804361 EGFL7_HUMAN (33-133): 5.22e-20: 92: 47.17		NOTC1_HUMAN (12-229): 5.06e-12: 75.3: 14.10
+	Hs
		537512 FBLN1_HUMAN (80-276): 6.69e-20: 95.5: 33.18		NID1_HUMAN (3473-3718): 1.32e-09: 67.1: 13.83
+	Hs
		612843 FBLN1_HUMAN (80-276): 6.69e-20: 95.5: 33.18		NOTC2_HUMAN (11-260): 3.49e-09: 66: 14.40
+	Hs
		980568 EGFL7_HUMAN (33-133): 5.22e-20: 92: 47.17		NOTC2_HUMAN (11-260): 3.49e-09: 66: 14.40
+	Hs
		804213 NOTC2_HUMAN (3-327): 4.89e-15: 80.7: 14.12		NOTC1_HUMAN (12-229): 5.06e-12: 75.3: 14.10
+	Hs
		296652 SLIT2_HUMAN (225-414): 5.12e-15: 80.7: 12.69		NOTC2_HUMAN (11-260): 3.49e-09: 66: 14.40