HitPredict

Interactor 1: PSD11 (O00231)
26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5)
Gene: PSMD11

Interactor 2: SEM1 (P60896)
26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1) (Deleted in split hand/split foot protein 1) (Split hand/foot deleted protein 1) (Split hand/foot malformation type 1 protein)
Gene: SEM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.928

Property	Details
Experiments	28396413, 16239144, 18775730, 15610744, 24515614, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DSS1_SEM1~PCI
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0008541 - proteasome regulatory particle, lid subcomplex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process and 1 others more... GO:0043248 - proteasome assembly
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 422 Hs			1 70
+	Hs
		893553 PSMD6_HUMAN (31-422): 3.57e-77: 246: 13.68		SEM1_HUMAN (1-70): 3.65e-23: 84.7: 100.00
+	Hs
		121978 PSD12_HUMAN (46-422): 1.57e-66: 220: 12.86		SEM1_HUMAN (1-70): 3.65e-23: 84.7: 100.00