HitPredict

Interactor 1: M4K3 (Q8IVH8)
Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3)
Gene: MAP4K3

Interactor 2: SH3G1 (Q99961)
Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1)
Gene: SH3GL1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	32640226
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 894 Hs			1 368
+	Hs
		1217585 M4K3_HUMAN (1-894): 0: 1060: 100.00		SH3G3_HUMAN (1-368): 1.31e-87: 270: 66.30
+	Hs
		1307427 M4K5_HUMAN (1-894): 0: 940: 65.41		SH3G1_HUMAN (1-368): 7.32e-90: 276: 100.00
+	Hs
		1217586 M4K3_HUMAN (1-894): 0: 1060: 100.00		SRBS1_HUMAN (235-363): 3.59e-15: 79.2: 25.95
+	Hs
		1191846 M4K3_HUMAN (1-894): 0: 1060: 100.00		SH3R1_HUMAN (305-361): 9.5e-13: 71.7: 49.18
+	Hs
		924683 M4K3_HUMAN (1-894): 0: 1060: 100.00		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		1052362 M4K5_HUMAN (1-894): 0: 940: 65.41		SRC8_HUMAN (35-362): 1.55e-37: 143: 12.16
+	Hs
		924984 M4K5_HUMAN (1-894): 0: 940: 65.41		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		924745 M4K1_HUMAN (6-893): 0: 782: 39.19		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		1023121 STK4_HUMAN (10-288): 2.22e-119: 373: 46.43		SHLB2_HUMAN (10-363): 1.2e-58: 196: 22.39
+	Hs
		1089313 STK24_HUMAN (9-291): 7.65e-116: 362: 46.67		RHG44_HUMAN (6-251): 8.5e-47: 172: 22.22
+	Hs
		1052339 STK26_HUMAN (3-291): 7.94e-118: 366: 46.05		SRC8_HUMAN (35-362): 1.55e-37: 143: 12.16
+	Hs
		596215 STK3_HUMAN (10-288): 2.29e-117: 368: 45.36		NEBU_HUMAN (7-363): 5.75e-36: 141: 16.13
+	Hs
		1023039 STK4_HUMAN (10-288): 2.22e-119: 373: 46.43		SPTN1_HUMAN (4-365): 1.47e-33: 134: 15.82
+	Hs
		682008 AKT1_HUMAN (6-341): 6.7e-134: 410: 23.70		SRBS1_HUMAN (235-363): 3.59e-15: 79.2: 25.95
+	Hs
		681922 AKT1_HUMAN (6-341): 6.7e-134: 410: 23.70		SH3R1_HUMAN (305-361): 9.5e-13: 71.7: 49.18
+	Hs
		682191 AKT2_HUMAN (5-344): 8.04e-134: 410: 22.92		SH3R1_HUMAN (305-361): 9.5e-13: 71.7: 49.18
+	Hs
		298951 AKT2_HUMAN (5-344): 8.04e-134: 410: 22.92		SRBS2_HUMAN (270-363): 9.46e-12: 68.6: 23.96
+	Mm
		82755 TNIK_MOUSE (6-290): 5.69e-73: 264: 48.32		B9EKJ1_MOUSE (4-365): 2.02e-33: 134: 16.62
+	Mm
		561157 TNIK_MOUSE (6-290): 5.69e-73: 264: 48.32		SPTN1_MOUSE (4-365): 2.12e-33: 133: 16.62
+	Dm
		993188 Q7KV89_DROME (10-313): 7.02e-77: 273: 45.99		GRAP_DROME (301-360): 1.2e-10: 62.4: 48.33