HitPredict

Interactor 1: HERC6 (Q8IVU3)
Probable E3 ubiquitin-protein ligase HERC6 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 6) (HECT-type E3 ubiquitin transferase HERC6)
Gene: HERC6

Interactor 2: UBQL2 (Q9UHD9)
Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)
Gene: UBQLN2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18535780
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1022 Hs			1 624
+	Hs
		1065054 HERC3_HUMAN (2-1014): 0: 945: 37.76		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		1065056 HERC3_HUMAN (2-1014): 0: 945: 37.76		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		1355829 HERC5_HUMAN (2-1014): 0: 916: 47.95		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		924302 HERC3_HUMAN (2-1014): 0: 945: 37.76		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Hs
		983264 UBE3A_HUMAN (402-1014): 1.36e-175: 536: 24.49		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		125787 WWP2_HUMAN (325-1014): 0: 554: 16.92		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		983269 UBE3A_HUMAN (402-1014): 1.36e-175: 536: 24.49		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		1336106 SMUF1_HUMAN (548-1014): 1.29e-164: 504: 21.65		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		1336119 SMUF1_HUMAN (548-1014): 1.29e-164: 504: 21.65		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		125739 WWP2_HUMAN (325-1014): 0: 554: 16.92		UBQL4_HUMAN (22-624): 2.17e-124: 382: 54.55
+	Hs
		125225 WWP2_HUMAN (325-1014): 0: 554: 16.92		BAG6_HUMAN (21-580): 4.44e-53: 198: 15.23
+	Hs
		983150 UBE3A_HUMAN (402-1014): 1.36e-175: 536: 24.49		DDI2_HUMAN (43-314): 6.26e-52: 185: 14.59
+	Hs
		924414 SMUF2_HUMAN (513-1014): 9.06e-175: 530: 20.93		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Hs
		924156 WWP1_HUMAN (515-1014): 0: 556: 19.62		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27
+	Hs
		125347 WWP2_HUMAN (325-1014): 0: 554: 16.92		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27
+	Dm
		89880 D5SHR3_DROME (651-1014): 1.96e-150: 455: 26.26		RL40_DROME (33-112): 3.08e-31: 120: 30.86