HitPredict

Interactor 1: PSD11 (O00231)
26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5)
Gene: PSMD11

Interactor 2: CSN6 (Q7L5N1)
COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP)
Gene: COPS6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	16169070
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	JAB~PCI, MitMem_reg~PCI, MitMem_reg~RPN6_C_helix
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 422 Hs			1 327
+	Hs
		897267 CSN2_HUMAN (8-419): 1.5e-88: 277: 22.80		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Mm
		291866 CSN2_MOUSE (8-419): 1.5e-88: 277: 22.80		CSN6_MOUSE (20-327): 3.02e-135: 388: 99.03
+	Hs
		121709 PSD11_HUMAN (1-422): 1.54e-117: 351: 100.00		PSMD7_HUMAN (37-317): 1.48e-97: 292: 24.48
+	Hs
		1184960 CSN4_HUMAN (4-422): 5.53e-72: 233: 14.62		CSN6_HUMAN (1-327): 1.8e-141: 404: 100.00
+	Dm
		1277032 CSN2_DROME (8-419): 1.91e-87: 274: 20.90		CSN6_DROME (21-327): 2.01e-122: 356: 59.74
+	Mm
		291852 CSN4_MOUSE (4-422): 7.3e-72: 233: 14.62		CSN6_MOUSE (20-327): 3.02e-135: 388: 99.03
+	Dm
		640773 PSD11_DROME (4-422): 6.96e-107: 323: 67.46		PSMD7_DROME (31-319): 9.82e-99: 296: 23.73
+	Mm
		102343 G3UXW9_MOUSE (116-421): 2.25e-55: 193: 17.41		CSN6_MOUSE (20-327): 3.02e-135: 388: 99.03
+	Dm
		1358198 CSN4_DROME (36-421): 1.46e-64: 214: 11.88		CSN6_DROME (21-327): 2.01e-122: 356: 59.74
+	Hs
		849202 PSMD6_HUMAN (31-422): 3.57e-77: 246: 13.68		PSMD7_HUMAN (37-317): 1.48e-97: 292: 24.48
+	Dm
		640777 PSMD6_DROME (31-422): 3.38e-72: 233: 13.93		PSMD7_DROME (31-319): 9.82e-99: 296: 23.73
+	Sc
		996269 RPN6_YEAST (39-421): 4.48e-81: 257: 45.36		RPN8_YEAST (39-323): 1.95e-84: 260: 22.08
+	Hs
		121968 PSD12_HUMAN (46-422): 1.57e-66: 220: 12.86		PSMD7_HUMAN (37-317): 1.48e-97: 292: 24.48
+	Dm
		1180711 PSD11_DROME (4-422): 6.96e-107: 323: 67.46		PSDE_DROME (24-295): 5.35e-53: 178: 12.13
+	Sp
		784775 RPN6_SCHPO (13-419): 1.56e-91: 284: 54.90		RPN11_SCHPO (31-299): 7.67e-52: 175: 14.62
+	Ce
		136316 CSN2_CAEEL (8-393): 5.7e-73: 238: 20.80		CSN6_CAEEL (32-310): 1.76e-63: 208: 30.54
+	Hs
		121895 PSD12_HUMAN (46-422): 1.57e-66: 220: 12.86		EIF3H_HUMAN (33-305): 9.03e-59: 194: 14.38
+	Ce
		136314 CSN2_CAEEL (8-393): 5.7e-73: 238: 20.80		CSN5_CAEEL (29-253): 1.44e-51: 176: 11.95
+	Dm
		1358521 PSMD6_DROME (31-422): 3.38e-72: 233: 13.93		PSDE_DROME (24-295): 5.35e-53: 178: 12.13
+	At
		799478 CSN1_ARATH (70-421): 1.51e-57: 196: 16.13		EIF3H_ARATH (18-252): 2.76e-52: 177: 14.84