HitPredict

Interactor 1: WDR75 (Q8IWA0)
WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog)
Gene: WDR75

Interactor 2: WDFY3 (Q8IZQ1)
WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy)
Gene: WDFY3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 830 Hs			1 3526
+	Hs
		152888 APAF_HUMAN (13-391): 4.56e-52: 199: 11.64		WDFY3_HUMAN (1-3526): 0: 4218: 100.00
+	Hs
		903352 WDR75_HUMAN (1-830): 2.39e-177: 533: 95.36		WDR5_HUMAN (2952-3290): 6.23e-71: 244: 15.32
+	Hs
		903174 TBL3_HUMAN (1-491): 1e-71: 253: 11.49		WDR5_HUMAN (2952-3290): 6.23e-71: 244: 15.32
+	Dm
		1358845 WDS_DROME (437-660): 3.66e-42: 159: 13.60		WDS_DROME (3028-3334): 2.27e-72: 249: 17.30
+	Hs
		903077 WDR5_HUMAN (477-696): 2.27e-34: 136: 15.25		WDR5_HUMAN (2952-3290): 6.23e-71: 244: 15.32
+	Hs
		792949 LIS1_HUMAN (475-709): 2.67e-32: 131: 10.92		WDR5_HUMAN (2952-3290): 6.23e-71: 244: 15.32
+	Hs
		903349 WDR5_HUMAN (477-696): 2.27e-34: 136: 15.25		WDR5B_HUMAN (2948-3292): 2.84e-69: 239: 16.57
+	Hs
		903551 NLE1_HUMAN (530-700): 1.91e-18: 91.2: 8.94		WDR5_HUMAN (2952-3290): 6.23e-71: 244: 15.32
+	Hs
		863397 COPA_HUMAN (5-364): 2.65e-16: 86: 12.59		WDR5_HUMAN (2952-3290): 6.23e-71: 244: 15.32
+	Hs
		1302754 TBL1R_HUMAN (329-669): 7.31e-53: 194: 10.14		RUFY1_HUMAN (3273-3521): 1.93e-30: 133: 23.26
+	Hs
		209416 WDR5_HUMAN (477-696): 2.27e-34: 136: 15.25		PLRG1_HUMAN (2934-3299): 1.42e-38: 155: 13.66
+	Hs
		245633 TBL1R_HUMAN (329-669): 7.31e-53: 194: 10.14		TBL1X_HUMAN (2950-3109): 6.05e-14: 80: 14.72
+	Hs
		245630 TBL1Y_HUMAN (324-669): 3.68e-52: 192: 11.11		TBL1X_HUMAN (2950-3109): 6.05e-14: 80: 14.72
+	Hs
		1309163 TBL1R_HUMAN (329-669): 7.31e-53: 194: 10.14		TBL1Y_HUMAN (2950-3107): 3.46e-13: 77.3: 13.04
+	Hs
		863526 COPA_HUMAN (5-364): 2.65e-16: 86: 12.59		RUFY1_HUMAN (3273-3521): 1.93e-30: 133: 23.26
+	Hs
		245546 TBL1X_HUMAN (396-696): 3.68e-30: 128: 13.74		TBL1X_HUMAN (2950-3109): 6.05e-14: 80: 14.72