HitPredict

Interactor 1: PSD12 (O00232)
26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55)
Gene: PSMD12

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	28190767, 33141564, 16196087
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 456 Hs			1 685
+	Hs
		476293 CSN4_HUMAN (45-448): 2.23e-100: 307: 19.37		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475555 CSN2_HUMAN (24-439): 1.11e-94: 294: 12.59		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		121666 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		UBC_HUMAN (1-685): 0: 846: 100.00
+	Sc
		477489 RPN5_YEAST (14-456): 3.37e-106: 324: 40.67		UBI4P_YEAST (381-685): 5e-122: 370: 95.74
+	At
		1092027 PS12A_ARATH (34-454): 1.75e-126: 376: 43.02		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	At
		1091832 PS12B_ARATH (34-455): 7.68e-123: 366: 43.37		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Sc
		477496 RPN6_YEAST (26-452): 2.93e-77: 249: 14.48		UBI4P_YEAST (381-685): 5e-122: 370: 95.74
+	Hs
		121987 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Mm
		477004 PSD12_MOUSE (1-456): 2.1e-154: 447: 97.59		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	At
		1092149 PSD11_ARATH (27-442): 4.61e-90: 281: 16.40		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Mm
		291853 CSN4_MOUSE (45-448): 1.94e-100: 307: 19.37		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		121730 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Mm
		476740 CSN2_MOUSE (24-439): 1.11e-94: 294: 12.59		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Rn
		897345 CSN2_RAT (24-439): 1.11e-94: 294: 12.59		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Mm
		476877 PSD11_MOUSE (27-443): 7.34e-90: 281: 15.67		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		121663 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69