HitPredict

Interactor 1: PSD12 (O00232)
26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55)
Gene: PSMD12

Interactor 2: PSA3 (P25788)
Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8)
Gene: PSMA3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37071682
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 456 Hs			1 255
+	Hs
		121942 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		PSA5_HUMAN (1-239): 4.52e-96: 283: 31.97
+	Hs
		121979 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		PSA6_HUMAN (4-242): 1.96e-95: 281: 29.34
+	Hs
		121938 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		PSA4_HUMAN (4-236): 5.31e-94: 278: 27.43
+	Hs
		121892 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		PSA7_HUMAN (7-237): 4.58e-93: 275: 31.76
+	Sc
		597278 RPN5_YEAST (14-456): 3.37e-106: 324: 40.67		PSA7_YEAST (1-246): 4.1e-111: 322: 51.20
+	Sc
		689218 RPN5_YEAST (14-456): 3.37e-106: 324: 40.67		PSA5_YEAST (1-255): 3.35e-94: 278: 32.57
+	Zm
		6694 A0A1D6E9U0_MAIZE (16-442): 4.34e-99: 305: 16.22		A0A1D6N969_MAIZE (1-250): 1.04e-96: 285: 59.30
+	Dm
		1180717 PSD11_DROME (28-443): 1.94e-86: 272: 15.21		PSA3_DROME (1-252): 1.3e-108: 315: 57.54
+	Hs
		893638 CSN2_HUMAN (24-439): 1.11e-94: 294: 12.59		PSA6_HUMAN (4-242): 1.96e-95: 281: 29.34
+	Sc
		597279 RPN6_YEAST (26-452): 2.93e-77: 249: 14.48		PSA7_YEAST (1-246): 4.1e-111: 322: 51.20
+	Hs
		121689 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSA5_HUMAN (1-239): 4.52e-96: 283: 31.97
+	Hs
		121719 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSA6_HUMAN (4-242): 1.96e-95: 281: 29.34
+	Hs
		121685 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSA4_HUMAN (4-236): 5.31e-94: 278: 27.43
+	Dm
		1180708 PSD11_DROME (28-443): 1.94e-86: 272: 15.21		PSA5_DROME (1-240): 1.81e-96: 284: 27.94
+	Hs
		121635 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		PSA7_HUMAN (7-237): 4.58e-93: 275: 31.76
+	Sc
		689219 RPN6_YEAST (26-452): 2.93e-77: 249: 14.48		PSA5_YEAST (1-255): 3.35e-94: 278: 32.57
+	Sc
		619398 RPN5_YEAST (14-456): 3.37e-106: 324: 40.67		PSA3_YEAST (8-198): 2.62e-34: 125: 35.42
+	Sp
		1013779 RPN6_SCHPO (25-438): 8.85e-86: 270: 14.39		PSA4_SCHPO (6-189): 3.96e-35: 127: 40.00
+	Dm
		611643 PSD11_DROME (28-443): 1.94e-86: 272: 15.21		PSA71_DROME (8-184): 2.38e-32: 120: 36.72
+	Sc
		619400 RPN6_YEAST (26-452): 2.93e-77: 249: 14.48		PSA3_YEAST (8-198): 2.62e-34: 125: 35.42